凹凸棒石对中药水煎液中丹参酮Ⅰ、丹参酮Ⅱ_A的吸附作用考察  

An inveatigation on adsorptive effect of attapulgite with TanshinoneⅠ and Tanshinone Ⅱ_A in traditional Chinese medicine decoction

作　　者：李晓强[1] 李平[1] 魏琴[1] 张德莉[1] 

机构地区：[1]兰州大学第二医院,甘肃兰州730030

出　　处：《中国生化药物杂志》2010年第2期114-117,121,共5页Chinese Journal of Biochemical Pharmaceutics

基　　金：甘肃省科技厅事业费项目(编号:QS061-C33-33)

摘　　要：目的考察凹凸棒石对中药丹参及复方丹参滴丸水煎提取液中有效成分丹参酮Ⅰ、丹参酮ⅡA的吸附作用。方法以煎出总固体物量和丹参酮Ⅰ、丹参酮ⅡA含量为指标,采用高效液相色谱法测定丹参酮Ⅰ、丹参酮ⅡA的含量,分别考察普通凹凸棒石与酸化凹凸棒石对中药丹参和复方丹参滴丸水煎提取液的吸附澄清作用。结果普通凹凸棒石对中药丹参及复方丹参滴丸水煎提取液中总固体物量无明显改善,对丹参酮Ⅰ、丹参酮ⅡA的含量略有影响;酸化凹凸棒石使中药丹参及复方丹参滴丸水煎液中浸出总固体物含量明显减少,对丹参酮Ⅰ、丹参酮ⅡA的含量影响较小。结论酸化凹凸棒石可作为丹参药材和复方丹参滴丸水煎提取液的吸附澄清剂。Purpose To investigate the adsorptive effect of attapulgite on TanshinoneⅠ and TanshinoneⅡA in decoction of Radix et Rhizoma Salviae Miltiorrhizae and Composite Dansen Pill.Methods Using the amount of solid component and the content of TanshinoneⅠ and TanshinoneⅡA as index,the adsorptive effect of common attapulgite and acidified attapulgite on decoction of Radix et Rhizoma Salviae Miltiorrhizae and Composite Dansen Pill was investigated respectively and the content of TanshinoneⅠ and TanshinoneⅡA was determined by HPLC.Results Common attapulgite could not markedly decreased the amount of solid component and had a little effect on the content of TanshinoneⅠand TanshinoneⅡA in decoction of Radix et Rhizoma Salviae Miltiorrhizae and Composite Dansen Pill.The acidified attapulgite could obviously decrease the amount of solid component and had a little effect on the content of TanshinoneⅠand TanshinoneⅡA in decoction of Radix et Rhizoma Salviae Miltiorrhizae and Composite Dansen Pill.Conclusion Acidified attapulgite could be used as adsorptive clarifier in decoction of Radix et Rhizoma Salviae Miltiorrhizae and Composite Dansen Pill.

关 键 词：凹凸棒石 丹参酮Ⅰ 丹参酮ⅡA 吸附 澄清 

分 类 号：R284.2[医药卫生—中药学]