1例人感染高致病性禽流感病例流行病学调查  

Epidemiological Investigation on a Human Case Infected with Highly Pathogenic Avian Flu

作　　者：邓茂铭 王定明[2] 周峻[1] 庄妍[2] 余春[2] 

机构地区：[1]黔东南州疾病预防控制中心,贵州凯里556000 [2]贵州省疾病预防控制中心,贵州贵阳550004

出　　处：《预防医学论坛》2010年第4期332-333,335,共3页Preventive Medicine Tribune

摘　　要：[目的]查明人感染高致病性禽流感病例传染源及传播途径,进一步阐明疾病自然史、流行病学特征,为疫情防控提供依据。[方法]对患者进行个案调查,对病人密切接触者进行登记,开展不明肺炎病例主动搜索、查阅病人临床资料,了解当地禽间禽流感的发病情况。[结果]患者发热(体温>38℃),胸片示肺炎征像,白细胞2.15×109/L,淋巴0.47～4.80,经正规抗生素治疗无效,气管痰液A/H5N1病毒核酸阳性,病毒分离阳性;有禽类接触史,当地有成批病死禽现象。确诊为人感染高致病性禽流感病毒(H5N1),经救治无效死亡。[结论]这是1例人感染高致病性禽流感死亡病例。[Objective]To find out the causes of infection and transmission routes of avian Flu case,to clarify the natural history and epidemiological characteristic of the disease,to provide basis for disease control and prevention.[Methods]A case study was carried out,close contacts with the patient were registered,to search for medical record of pneumonia cases with unknown origin,to look up patients＇ clinical data to understand the status of avian flu from bird to bird transmission.[Results]The patient had a fever（with a temperature more than 38 ℃）,chest X-ray suggested the symptom of pneumonia,the white blood cell count was 2.15×10^9/L,lymphocyte was 0.47-4.80.It was failure after the treatment with general antibiotics.Tracheal sputum sample was positive for A/H5N1 RNA and virus isolation.The patient had the contact history with poultry,sick or dead poultry can be found in the region,the case was infected with highly pathogenic avian influenza virus（H5N1） and died after failure in emergency treatment.[Conclusion]This is a case died of human infection with highly pathogenic avian flu.

关 键 词：人感染高致病性禽流感 流行病学调查 

分 类 号：R511.7[医药卫生—内科学]