米非司酮配伍米索前列醇在终止12～14周妊娠钳刮术中的应用  

The application of Mifepristone complicated Misoprostol for the termination of pregnancy with 12～14 gestational weeks in the embryulcia surgery

作　　者：张蓉 

机构地区：[1]中江县计划生育服务站女性节育科,四川德阳618100

出　　处：《中国计划生育和妇产科》2010年第2期53-55,共3页Chinese Journal of Family Planning & Gynecotokology

摘　　要：目的探讨临床上钳刮术前应用米非司酮配伍米索前列醇终止l2～14周妊娠的临床效果。方法选取110例自愿要求引产的l2～14周妊娠妇女,分为两组,观察组口服米非司酮2天后阴道后穹隆放置米索前列醇400μg;对照组在术前行羊膜腔内注射利凡诺100mg。记录用药时间、宫缩发动时间、胎儿胎盘娩出时间等。结果两组流产率比较差异具有显著性(P<0.05);术后两组在子宫出血、胎盘胎膜残留方面差异有显著性(P<0.05),宫颈撕裂发生无显著性差异(P>0.05)。结论行钳刮术前应用米非司酮配伍米索前列醇终止l2～14周妊娠,具有流产率高、胎盘胎膜残留率少、子宫出血发生率少等优点,克服了单一钳刮术所致的不良结局,以及利凡诺羊膜腔内引产穿刺困难的缺点,值得临床上进一步推广和应用。Objective To study the clinical effect of Mifepristone complicated Misoprostol for the termination of pregnancy with 12~14 gestational weeks before the embryulcia surgery. Methods The pregnancy women with 12~14 gestational weeks willing to terminate the pregnancy were divided into observation group and control group. The pregnancy women in observation group were taken Mifepristone for two days and taken Misoprostol 400 ug in posterior fornix. Other pregnancy women in control group were injected rivanol 100 mg to amniotic cavity. The administration time,the time of uterine contraction and the delivery time of the fetus and placenta were recorded. Results There was significant difference of abortion rate,uterine bleeding and retained placenta and fetal membrance（P0.05） between two groups. While there was no difference of laceration of cervix between two groups（P0.05）. Conclusion Mifepristone complicated Misoprostol for the termination of pregnancy with 12~14 gestational weeks before the embryulcia surgery was less incidence rate of retained placenta and fetal membrance and uterine bleeding,at the same time it overcame the adverse outcomes resulting from the embryulcia surgery and shortcomings of induction of labor with rivanol injected to amniotic cavity. It was worth generalization and applization.

关 键 词：米非司酮 米索前列醇 利凡诺 钳刮术 终止妊娠 

分 类 号：R719[医药卫生—妇产科学]