正交设计法优化炒牛蒡子的炮制工艺  

Processing for Arctium Lappa with orthogonal test

作　　者：王平 韩丽妹[2] 王建新[2] 

机构地区：[1]上海德华国药制品有限公司,上海201400 [2]复旦大学药学院,上海201203

出　　处：《中成药》2010年第4期607-610,共4页Chinese Traditional Patent Medicine

摘　　要：目的:采用正交试验优化炒牛蒡子的炮制工艺。方法:建立了同时测定牛蒡苷和牛蒡苷元的高效液相色谱法;以牛蒡苷和牛蒡苷元含量为指标,采用两因素三水平正交设计优选炒牛蒡子炮制工艺。结果:随着炒制温度的升高和炒制时间的延长,牛蒡苷的含量下降,牛蒡苷元的含量增加。优化得到的炮制工艺为:加热至300℃清炒4～5 min。结论:该炮制工艺稳定可行,可用于炒牛蒡子的生产。AIM： To optimize the parameters of processing for Arctium Lappa.METHODS： The contents of arctiin and arctigenin in Arctium Lappa were determined with HPLC,and the total yields of them were chosen as in-dex.The orthogonal test was adopted to acquire the optimum technology for processing Arctium Lappa.RESULTS： The study showed that the best processing parameters for Arctium Lappa consisted of 300 ℃ of the drying tempera-ture and 4-5 minutes of processing time.CONCLUSION： The processing method is reasonable,stable and reliable,and can be used in commercial production.

关 键 词：炒牛蒡子 炮制工艺 正交设计 牛蒡苷 牛蒡苷元 高效液相色谱 

分 类 号：R283[医药卫生—中药学]