OHSS高危胚胎移植与全胚胎冷冻移植不孕患者结局分析  

Outcome Analysis between IVF-ET Cycle and Whole Embryo Freezing and Thawing Cycle in High-Risk OHSS Patients

作　　者：鲁振宇[1,2] 徐凤琴[3] 张云山[3] 糜若然[1] 

机构地区：[1]天津医科大学总医院,300052 [2]天津市中心妇产科医院 [3]天津市中心妇产科医院生殖中心

出　　处：《天津医药》2010年第3期189-191,共3页Tianjin Medical Journal

摘　　要：目的:分析比较存在卵巢过度刺激综合征(OHSS)高危因素患者进行新鲜周期体外受精-胚胎移植(IVF-ET),以及同期为预防OHSS的发生进行全胚胎冷冻,后进行解冻胚胎移植2种治疗方法的效果。方法:选择2005年1月—2008年4月在本中心进行IVF-ET治疗的患者。OHSS高危人群但行新鲜周期胚胎移植患者239例,为A组;同期行全胚胎冷冻,2～3个周期后行胚胎解冻移植的患者164例,解冻周期203例次,为B组。对2组患者超促排卵(COH)情况、获卵数、冷冻胚胎数、新鲜周期以及解冻周期临床妊娠率等情况进行比较。结果:A组促卵泡生成素(Gn)始量以及Gn总量高于B组(P<0.01);A组注射人绒毛膜促性腺激素(hCG)日雌激素(E2)水平、发育卵泡数、获卵数、冷冻胚胎数低于B组(P<0.01);2组患者的年龄、COH时间、OHSS的发生率以及临床妊娠率差异无统计学意义(P>0.05)。结论:在IVF-ET时,全胚胎冷冻然后行胚胎解冻移植,与新鲜周期移植比较并未影响不孕症患者的治疗结局。Objective： To investigate the effective method to avoid the ovarian hyperstimulation syndrome （OHSS） in infertile patients underwent in vitro fertilization-embryo transfer （IVF-ET） and whole embryo freezing and thawing 2-3 cycles after egg retrieval. Methods： The controlled ovarian hyperstimulation （COH）, the number of retrieved oocytes, the number of embryo freezing, and clinical pregnancy rate were compared between 239 patients with the ET cycle（group A） and 164 patients with whole embryo freezing and thawing （group B）. Results： The levels of initial dosage of gonadotropins（Gn） and total dosage of Gn were higher in group A compared with those of group B（P 0.01）. The level of estradiol（E2） on day of human chorinonic gonadotrophin （hCG）, the number of retrieved oocytes and the number of embryo freezing were lower in group A compared with those of group B （P 0.01）. There were no differences in patient age, COH, rate of OHSS and clinical pregnancy rate between group A and group B. Conclusion： Freezing the whole embryos and thawing ET 2-3 cycles after egg retrieval didn’t influence the treatment results in infertile patients .

关 键 词：胚胎移植 受精 体外 卵巢过度刺激综合征 多囊卵巢综合征 冷冻 低温保存 

分 类 号：R321-33[医药卫生—人体解剖和组织胚胎学]