肺泡蛋白沉积症临床治疗的CT影像学评估  

Pulmonary Alveolar Proteinosis：Assessment with Chest Computed Tomography of Clinical Treatment

作　　者：周剑[1] 孙宪昶[2] 吕锐[1] 周海[1] 高培毅[3] 

机构地区：[1]首都医科大学附属北京天坛医院放射科,北京100050 [2]武警总医院CT科 [3]北京天坛医院神经影像中心

出　　处：《实用放射学杂志》2010年第3期344-346,353,共4页Journal of Practical Radiology

摘　　要：目的探讨CT影像在肺泡蛋白沉积症（PAP）临床疗效判定中的价值。方法回顾性分析9例PAP患者肺泡灌洗前后胸部CT影像资料、肺功能检查结果及血气分析检测指标；在CT图像上对病变范围进行影像学量化评分，并与肺功能及血气分析指标进行相关性分析。结果9例PAP患者肺泡灌洗前胸部CT具有特征性影像表现，病变范围量化评分与肺总量（TLC）、用力呼吸肺活量（FVC）、一氧化碳弥散量（DLCO）、动脉血氧分压（PaO2）和动脉血氧饱和度（SaOz）呈显著负相关，P值均〈O．05。肺泡灌洗后肺功能各项指标均有不同程度改善，Pa02、Sa02较灌洗前明显增加。结论胸部CT检查可为PAP临床诊断、治疗及预后评估提供客观依据。Objective To study the value of chest CT in evaluating the curative effect for pulmonary alveolar proteinosis （PAP）. Methods The chest CT findings and the results of pulmonary function tests and blood gas analysis in 9 patients with PAP before and after bronchoalveolar lavage （BAL） were reviewed retrospectively. The lesions in extent were scored on CT images. The relationship between the imaging scores and pulmonary function tests as well as blood gas were analysed. Results The results of pulmonary func- tion tests such as TLC,PVC,PEV1 and DLCO were improved to a certain degree after BAL in 9 patients with PAP; PaO2 and SaO2 were increased significantly after BAL{P^0.05）. CT scores before BAL correlated significantly with TLC , PVC , DLCO , PaOz and SaO2 （P%0.05）. Conclusion CT examination can provide objective imformations for clinical diagnosis,treatment and prognostic evaluation of pulmonary alveolar proteinosis.

关 键 词：肺 肺泡蛋白沉积症 支气管肺泡灌注 体层摄影术 X线计算机 

分 类 号：R563[医药卫生—呼吸系统] R814.42[医药卫生—内科学]