P2嘌呤受体亚型与冠心病的关系  

Relationship between P2 purinoceptor subtypes and coronary heart disease

作　　者：聂永莉[1,2] 张玉芹[1] 

机构地区：[1]武汉科技大学医学院生理学教研室,湖北武汉430065 [2]汉江医院心内科,湖北丹江口442700

出　　处：《基础医学与临床》2010年第4期434-436,共3页Basic and Clinical Medicine

基　　金：湖北省自然科学基金(2004ABA152);湖北省教育厅重点项目(D20081108)

摘　　要：嘌呤受体包括P1受体和P2受体。本文综述了P2嘌呤受体的多个亚型与冠心病之间的关系,P2Y1、P2Y2、P2Y11和P2X7受体参与动脉粥样硬化斑块中的炎性反应,P2X3受体参与了心绞痛的伤害性反应,P2X4受体参与血管重塑和增强非梗死区心肌的收缩力,P2Y2和P2Y6受体与冠脉介入术后再狭窄的形成有关,P2Y11受体的多态性可增加心肌梗死的风险,P2Y1、P2Y12和P2X1受体则参与了血栓的形成。研制P2嘌呤受体各亚型特异性的激动剂和拮抗剂对开发治疗冠心病的新药具有重要意义。In this article we review the relation between P2 purinoceptor subtypes and coronary heart disease（CHD）.P2Y1、P2Y2、P2Y11 and P2X7 receptors are related to inflammatory reaction in atherosclerosis plaque.P2X3 receptor plays an important role in anginal nocuity response.P2X4 receptor is involved in vascular remodeling and enhancement of myocardial contractility in non-infarct zone.P2Y2 and P2Y6 receptors are involved in restenosis.A polymorphism in P2Y11 receptors increase the risk of myocardial infarction.P2Y1、P2Y12 and P2X1 receptors play a role in thrombotic formation.The specific agonist and antagonist of P2 purinoceptor subtypes could be potential targets for new drugs to treat CHD.

关 键 词：嘌呤受体 ATP 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]