磷酸钙骨水泥复合微小颗粒骨修复兔桡骨缺损  

Combination of calcium phosphate cement and micromorselized bone for repairing rabbit radius defect

作　　者：梁建平[1] 刘兴炎[1] 葛宝丰[1] 陈克明[1] 熊发明[1] 李荣刚[1] 

机构地区：[1]兰州军区兰州总医院创伤外科,兰州730050

出　　处：《中国矫形外科杂志》2010年第6期486-488,共3页Orthopedic Journal of China

基　　金：全军"十一五"医药卫生科研基金资助项目(编号:06MA090);甘肃省自然科学基金资助项目(编号:0710RJZA068)

摘　　要：[目的]证实磷酸钙骨水泥复合少量自体颗粒骨修复骨缺损的效果,为临床使用提供依据。[方法]手术造成日本大耳白兔双侧桡骨中段15 mm缺损,一侧植入磷酸钙骨水泥与自体颗粒骨以3∶1复合的材料,做为实验组;另一侧植入单纯的磷酸钙骨水泥,做为对照组。在不同的时间点行X线、骨密度、最大扭矩检测,分析实验组及对照组的成骨性能和材料降解程度。[结果]X线检查发现:实验组材料明显促进成骨,8周时材料周围有明显的骨痂,16周时缺损完全修复、材料完全降解,优于对照组;8、16周时,实验组单位面积的骨矿盐含量均高于对照组,统计学检测,P<0.01;16周时实验组和对照组的最大扭矩分别为:(0.843±0.016)mN、(0.540±0.029)mN,统计学检验P<0.01。[结论]磷酸钙骨水泥与自体颗粒骨以3∶1复合后明显促进了缺损修复和材料降解。[Objective]To confirm the effect of combination of calcium phosphate cement and small amounts of autoallergic micromorselized bone for reparing bone defect and provide the basis for clinical use.[Method]The animal models of bilateral radius defect were created by surgery on Japan white big ear rabbits.The combination with a ratio of 3 to 1 in one lateral leg was implanted in experimental group,and calcium phosphate cement was used in the control group.The X-rays,bone density,and maximum torsional moment were carried out at different time points,and osteogenesis and degradation of the materials in the two groups were analyzed.[Result]Enhancement of osteogenesis was found in the experimental group,and the materials were enclosed significantly by bony callus at the 8^th week,the defects were repaired and the materials were degraded completely at the 16^th week.The bone mineral content in the experimental group was higher than that in the control group（P〈0.01）.The maximum torsional moment was（0.843±0.016）mN in the experimental group and（0.540±0.029）mN in the control group（P〈0.01）.[Conclusion]The combination of calcium phosphate cement and morselized bone by a ratio of 3 to 1 can significantly improve the defect repair and materials degradation.

关 键 词：磷酸钙骨水泥 微小颗粒骨 骨缺损 兔 

分 类 号：R687[医药卫生—骨科学]