胎儿小脑发育的MRI研究及其意义  

The development of fetal cerebellum assessed by MR images

作　　者：刘菲[1] 李振平[1] 刘树伟[1] 张忠和[1] 林祥涛[1,2] 耿鹤群[1] 徐君海[1] 

机构地区：[1]山东大学医学院断层影像解剖学研究中心,济南250012 [2]山东省医学影像研究所,济南250021

出　　处：《中国临床解剖学杂志》2010年第2期155-158,共4页Chinese Journal of Clinical Anatomy

基　　金：山东省自然科学基金资助项目(Y2006C28)

摘　　要：目的应用胎儿标本MR图像测量小脑的径线和体积,获得小脑发育指标的正常范围。方法87例无中枢神经系统疾病的胎儿标本,胎龄为14～40周,行3.0TMR扫描,使用Amira软件分别测量小脑径线:横径(TCD),前后径(A-PD)、上下径(小脑蚓长度)及小脑体积(CV),并分析它们与胎龄的关系。结果小脑横径、前后径、上下径均随胎龄呈直线增长趋势,TCD=0.165FA-1.410(r2=0.929,P<0.05);A-PD=0.091FA-0.717(r2=0.833,P<0.05);(vermis length)=0.108FA-0.832(r2=0.859,P<0.05);小脑体积随胎龄增加呈指数曲线增长,CV=0.034exp(FA/5.918)(r2=0.915,P<0.05),小脑体积的倍增时间为4.1周。结论胎儿标本MR图像可以清晰并准确的显示胎儿小脑大小的发育变化,所得测量结果可为临床宫内胎儿小脑发育状况的诊断与评估提供解剖和影像学依据。Objective TomeasurethevolumeandmaindimensionsoffetalcerebellumwithMRI,and obtain the ranges of their normal values. Methods 87 fetal specimens without CNS diseases aged from 14-40 gestational weeks were scanned under 3.0T MRI. The cerebellar transverse diameter （TCD）,anteroposterior diameter （A-PD）,vermis length and cerebellar volume were then calculated by Amira software. Lastly the relationship between these values with fetal age（FA） was analyzed statistically. Results The TCD,A-PD and vermis length increased linearitily following the growth of the fetuses [TCD=0.165FA -1.410; A-PD=0.091FA -0.717; vermis length=0.108FA -0.832]. The relationship between cerebellar volume （in cubic centimeters） and FA （in weeks） was well described by a single exponential function [CV=0.034 exp （FA/5.918）]. The doubling time of CV was about 4.1 weeks. Conclusions The development of fetal cerebellum could be displayed and quantified by 3.0T MRI,which is valuable for clinical diagnosis and evaluation of fetal development in vivo.

关 键 词：胎儿 小脑 MR 标本 

分 类 号：R323.1[医药卫生—人体解剖和组织胚胎学] R322.81[医药卫生—基础医学]