亚低温对急性重型颅脑损伤患者血清C反应蛋白浓度的影响  

Effect of mild hypothermia therapy on the concentration of plasma C-Reactive protein following acute severe brain injuries

作　　者：陈再丰[1] 许信龙[1] 傅小君[1] 魏晓捷[1] 潘红松[1] 谢青松[1] 史斌群[1] 

机构地区：[1]浙江省慈溪市人民医院神经外科

出　　处：《中国临床药理学与治疗学》2010年第2期210-213,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：宁波市自然科学基金资助项目(2008A610093)

摘　　要：目的:通过动态观察亚低温对急性重型颅脑损伤患者血清C反应蛋白(CRP)浓度的影响,探讨亚低温在急性重型颅脑损伤治疗中的作用。方法:将120例急性重型颅脑损伤患者(观察组)随机分为亚低温组和常规组。亚低温组在常规治疗的基础上加用亚低温治疗,直肠温度维持在33～35℃,持续3～5 d。所有患者于入院6 h内及入院后第2～6天应用速率放射比浊法动态检测血清CRP浓度,结合临床表现及伤后1个月格拉斯哥预后评分(GOS评分)进行比较分析。将本院体检的正常成年人30例作为对照组。结果:观察组血清CRP浓度明显高于对照组(P<0.05);亚低温组血清CRP浓度明显低于常规组(P<0.05);观察组中预后恶劣组血清CRP浓度明显高于预后良好组(P<0.05)。结论:急性重型颅脑损伤后血清CRP浓度升高,早期应用亚低温能够降低血清CRP浓度,保护神经功能,改善预后。AIM： To observe the effect of mild hypothermia therapy on concentration of plasma C-reactive protein following acute severe brain injuries and to explore the treatment effect of mild hypothermia on acute severe brain injury patients. METHODS： A total of 120 patients with acute severe brain injuries were divided into mild hypothermia therapy group and general group randomly. The patients of mild hypothermia therapy group were treated with mild hypothermia therapy besides general treatment. Serial concentrations of C-reactive protein in serum were measured in all patients from 6 h to 6 d after hospitalization. RESULTS： The concentration of C-reactive protein in serum of both groups were significantly higher than those of normal group（P〈0.05）; The concentration of C-reactive protein in serum of mild hypothermia therapy group were significantly lower than those of general group（P〈0.05）; The concentrations of C-reactive protein in serum in the group with poor prognosis were higher than those in the group with sound prognosis. CONCLUSION： The concentration of C-reactive protein in serum was elevated significantly after acute severe brain injuries, mild hypothermia could decrease the concentration of C-reactive protein in serum, protect the neurofunction and improve the prognosis.

关 键 词：亚低温 急性重型颅脑损伤 C反应蛋白 

分 类 号：R651[医药卫生—外科学]