miRNA在糖尿病中的研究进展  

Research progress of miRNA in diabetes

作　　者：龚志成[1,2] 黄琼[1] 刘昭前[1] 

机构地区：[1]中南大学临床药理研究所湖南省遗传药理学重点实验室 [2]中南大学湘雅医院药剂科

出　　处：《中国临床药理学与治疗学》2010年第2期214-218,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金项目(30572230;30873089);湖南省自然科学基金重点项目(08JJ3058);湖南省"芙蓉学者计划特聘教授"(湘教通[2006]312号)

摘　　要：已发现大量微小RNA(microRNA,miRNA)调节编码糖尿病相关蛋白基因的表达。miRNA表达量或功能的变异与多种疾病相关。已有研究报道miRNA与糖尿病相关,miRNA参与调节胰岛β细胞的功能且糖尿病状态下组织内miRNA会发生变化。miRNA成为糖尿病治疗的潜在靶点。本文就近年来miRNA在糖尿病方面的研究进展进行综述。The discovery hundreds of small RNA molecules, called microRNA, with the potential to modulate the expression of the majority of the protein-coding genes has revolutionized in the diabetes field. Moreover, alterations in the level or function of microRNA are associated with an increasing number of diseases. We present evidence for the involvement of microRNA in diabetes mellitus, by outlining the contribution of these microRNA molecules in the control of pancreatic β-cell functions and by reviewing recent studies reporting changes in microRNA expression in tissues. MicroRNA holds great potential as therapeutic targets. In this article, the researches of miRNA in diabetes and their potential for molecular therapy were summarized.

关 键 词：微小RNA 糖尿病 基因表达 胰岛 RNA干扰 

分 类 号：R968[医药卫生—药理学]