美沙酮维持治疗对海洛因依赖者情绪状态的影响  

EFFECT OF METHADONE MAINTENANCE TREATMENT ON EMOTIONAL STATUS OF HEROIN DEPENDENT PATIENTS

作　　者：李岚[1] 张昌勇[1] 沈君[1] 

机构地区：[1]华中科技大学同济医学院附属精神卫生中心,武汉430022

出　　处：《中国药物依赖性杂志》2010年第2期112-115,共4页Chinese Journal of Drug Dependence

摘　　要：目的:了解美沙酮维持治疗(MMT)对海洛因依赖者情绪状态的影响,为维持治疗提供指导。方法:使用抑郁自评量表(CES-D),分别对131例参加美沙酮维持治疗一年以上的海洛因依赖者及120例来我院进行自愿戒毒的海洛因依赖者(对照组)急性脱毒前、后予以问卷调查,将两组人群的CES-D总评分及各单项评分予以比较、分析。结果:64.1%的美沙酮维持治疗者肯定有抑郁症状,对照组抑郁症状检出率为64.2%,两组抑郁症状患病率差异无统计学意义(P>0.05)。美沙酮维持治疗组常见抑郁症状依次为无愉快感(57.3%)、空虚感(56.5%)、自卑感(51.9%)、绝望感(45.0%),而对照组依次为自卑感(64.2%)、绝望感(59.2%)、无愉快感(55.8%)、空虚感(52.5%);对照组脱毒前、后抑郁症状改变差异无统计学意义(P>0.05);与对照组相比(治疗前后),MMT能显著改善自卑感、绝望感等抑郁症状,差异有统计学意义(P<0.05),但对无愉快感、空虚感无改善。结论:美沙酮维持治疗对抑郁状态总体无改善作用,但一定程度上具有部分改善抑郁情绪不同症状的作用,如降低患者的自卑感和绝望感。在治疗过程中,必须高度重视美沙酮维持治疗者的情绪状态以提高MMT治疗效果。Objective：To explore the effect of methadone maintenance treatment（MMT） on the emotional status of heroin dependent patients with heroin dependence and provide guidance for MMT.Methods： Patients including 131 cases on MMT over a year and 120 inpatients（as control） on detoxification voluntarily were assessed by CES-D.The results were analyzed and compared.Results：Obvious depression was discovered in 64.1% of MMT patients and 64.2% of the controls and no significant difference was observed between the two groups（P0.05）.The common depression symptoms in MMT group were loss of enjoyment（57.3%）,feeling hollow（56.5%）,reduced self-esteem（51.9%） and despairing（45.0%）;while in the control group were reduced self-esteem（64.2%）,despairing（59.2%）,loss of enjoyment（55.8%） and feeling hollow（52.5%）.No significant changes in the common depression symptoms were found after detoxification in the control group（P0.05）.Compared with the control group（pre and post defoxification）,MMT patients improved in the depression symptoms such as reduced self-esteem and despairing,showing statistical significance（P0.05/P0.01）,no changes had taken place in loss of enjoyment and feeling hollow.Conclusion： In general,MMT is not able to change the depression status of heroin dependent patients,but can partly lessen some depression symptoms such as reduced self-esteem and despairing,which suggests that during the process of MMT,attention should be paid to the emotional status of MMT patients so as to improve MMT efficacy.

关 键 词：美沙酮维持治疗 海洛因依赖者 情绪状态 

分 类 号：R512.91[医药卫生—内科学]