鹿茸提取物对糖尿病小鼠血糖血脂的影响  

The serum glucose/lipid effect extraction from red deer pilose antler on diabetic ICR mice induced by alloxan

作　　者：刘瑜[1] 王振宇[1,2] 周丽萍[1] 

机构地区：[1]东北林业大学林学院,哈尔滨150040 [2]哈尔滨工业大学食品学院,哈尔滨150001

出　　处：《食品科技》2010年第4期218-221,共4页Food Science and Technology

摘　　要：目的:研究马鹿鹿茸提取物对四氧嘧啶(ALX)诱导糖尿病小鼠的降糖作用。方法:用ALX成功地制造了糖尿病小鼠模型,把鹿茸提取物(RD)分为低(1.6mg/g)中(3.2mg/g)高(4.8mg/g)3个剂量组,连续灌胃4周。结果:与模型对照组相比,RD极显著地降低ALX糖尿病小鼠血糖、血脂水平和总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)含量,提高麦芽糖酶(CAT)活性和高密度脂蛋白胆固醇(HDL-C)含量,同时可调节糖尿病小鼠的饮食水平。结论:RD能有效的控制糖尿病小鼠血糖水平,纠正其脂质代谢紊乱及预防动脉粥样硬化(AI)。Objective：To study the serum glucose/lipid effect of extration from red deer（RD） pilose antler on diabetic ICR Mice induced by Alloxan（ALX）.Methods：The ALX-induced diabetic ICR Mice were randomLy divided into three dose groups and were given intragastrically for 4w i.e.low（1.6 mg/g）,mid（3.2 mg/g） and high（4.8 mg/g） according to RD.The levels of serum glucose,blood-liquid,TC,TG,LDL-C,CAT and HDL-C were assayed.Results：Compared with the model control group,RD could not only reduce the levels of serum glucose and blood-liquid,but also reduce the contents of TC,TG and LDL-C.Meanwhile the activity of CAT and the content of HDL-C were obviously improved and the diet in ALX-induced diabetic ICR Mice was adjusted.Conclusions：RD can effectively control the levels of serum glucose/liquid,correct its lipid metabolism disorder and prevent the atherosclerosis（AS） in ALX-induced diabetic ICR Mice.

关 键 词：马鹿鹿茸 糖尿病 血糖血脂 

分 类 号：R284.2[医药卫生—中药学]