老年冠心病患者MTHFR基因多态性研究  

The relationship between coronary heart disease and methylenetetrahy drofolate reductase in elderly

作　　者：李晓波[1] 李燕[1] 李亚平[1] 王卫[1] 周英[1] 邓紫玉[1] 屈晓雯[1] 

机构地区：[1]云南省第一人民医院内干科,昆明650032

出　　处：《中国实用医药》2010年第12期24-25,共2页China Practical Medicine

摘　　要：目的探讨N5,N10亚甲基四氢叶酸还原酶(MTHFR)基因多态性与老年冠心病的关系。方法应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)检测114例冠心病患者及31例对照组MTHFR基因多态性。结果冠心病组与对照组MTHFR基因C677T位点各基因型频率、T等位基因频率、T/T纯合子频率差异无显著性差异。结论MTHFR基因多态性与老年冠心病无显著关系,不能被确定为老年冠心病的独立危险因素。Objective To observe the relationship of polymorphisms in methylenetetrahydrofolate reductase（MTHFR）and coronary heart disease（CHD）in the elderly.MethodsPolymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）was used to analyze the MTHFR C677T genotypes in a sample of 114 cases with documented CHD and 31 controls among the elderly patients.ResultsThere were no differences in genotype frequency or allele frequencies between CHD and the control.ConclusionMTHFR gene mutation cannot ascertained to be independent risk of coronary heart disease in the elderly.

关 键 词：MTHFR基因多态性 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]