人乳头瘤病毒在国人宫颈病变中感染及型别分布特征的Meta分析  

Meta-analysis of Human Papillomavirus (HPV) Prevalence and Type Distribution in Cervical Lesions in Chinese Population

作　　者：张东红[1] 林美珊[2] 

机构地区：[1]汕头大学医学院心血管研究中心,广东省汕头市515041 [2]汕头大学医学院第二附属医院检验科

出　　处：《中国全科医学》2010年第12期1287-1290,共4页Chinese General Practice

基　　金：广东省汕头市科技计划项目;汕府科([2009]70-8)

摘　　要：目的探讨人乳头瘤病毒(human papillomavirus,HPV)在我国妇女宫颈病变中的感染及型别分布特征。方法采用Meta分析法综合评价1999年1月—2008年9月在国内发表的有关HPV在宫颈组织中感染及型别分布的相关研究。结果HPV在我国妇女宫颈病变中平均感染率为46.51%(5632/12110),其中北方地区HPV平均感染率高于南方(55.67%和42.06%,P<0.01)。全国范围内前5位常见高危型HPV分布依次为:HPV-16、HPV-58、HPV-18、HPV-52和HPV-33;南、北方除HPV-16型外其他主要型别分布有一定的差异。在确诊的宫颈病变组织中,HPV的感染率与宫颈病变程度呈正相关(r=0.815,P<0.01),HPV-16在宫颈的各级病变中最为常见,其感染率与宫颈病变程度呈正相关(r=0.823,P<0.01)。结论HPV的感染率及型别分布在我国不同地区及不同病变的宫颈组织中均有一定的差异,总体以高危型HPV-16、HPV-58和HPV-18感染为主。Objective To explore the overall prevalence and type distribution of human papillomavirus（HPV） in the cervical lesions in Chinese women.Methods Meta-analysis was conducted on studies published from Jan 1999 to Sep 2008 to evaluate synthetically the relationship between HPV infection and the lesions of Cervix.Results The overall HPV prevalence was 46.51%（5632/12110） in cervical lesion in Chinese women.HPV positive rate was higher in northern China than in southern （55.67% VS 42.06%,P0.01）.The 5 commonest HPV types in China were HPV-16,HPV-18,HPV-58,HPV-52 and HPV-33.Except HPV-16,the distribution of other common types of HPV varied with regions.The rate of HPV infection was positively correlated with the degree of cervical lesions（r=0.815,P0.01）.HPV-16 was the commonest type in all degrees of cervical lesions and its infection rate was positively correlated with the degree of cervical lesions（r=0.823,P0.01）.Conclusion HPV infection rate and distribution vary in some extent in different regions and in various lesions of cervical tissue,mainly high-risk HPV-16,-58,-18.

关 键 词：人乳头瘤病毒 宫颈 感染 

分 类 号：R711.32[医药卫生—妇产科学]