地塞米松雾化吸入对哮喘患者诱导痰液中ECP、TNF-α、sIL-2R水平的影响  

Effect of Dexamethasone inhalation on ECP,TNF-α,slL-2R levels in asthmatic patients induced sputum

作　　者：谢柏梅[1] 杨瑜莹[1] 江玲[1] 

机构地区：[1]解放军第451医院干部病房,西安710054

出　　处：《陕西医学杂志》2010年第1期33-34,共2页Shaanxi Medical Journal

摘　　要：目的:诱导测定哮喘患者痰液ECP、TNF-α、slL-2R水平,评价吸入地塞米松防治哮喘的作用。方法:采用酶联免疫法及荧光免疫法对40例轻中度哮喘患者在吸入激素前后测定痰液中嗜酸细胞阳离子蛋白(ECP)、肿瘤坏死因子-α(TNF-α)、可溶性白细胞介素2受体(slL-2R)水平。结果:吸入激素后诱导痰液ECP水平由300±122μg/L降至146±96μg/L、TNF-α由280±135ng/L降至132±53ng/L、slL-2R由497±136kU/L降至328±97kU/L。哮喘患者吸入激素前ECP与TNF-α,slL-2R均呈显著正相关(r=0.58,0.62,P<0.05)。吸入激素后各指标间无显著相关性。结论:吸入激素后哮喘患者诱导痰液中ECP、TNF-α、slL-2R浓度比吸入激素前明显降低。吸入激素可明显抑制气道炎性反应,其作用机制可能与抗炎作用有关。Objective：To investigate the effects of inhaled Dexamethasone on eosinophil cationic protein（ECP）,tumor necrosis factor α（TNF-α） and soluble interleukin 2 receptor（slL-2R）levels in asthmatic patients induced sputum.Methods：The ECP,TNF-α and slL-2R levels in induced sputum in 40 patients with mild-moderate asthma were detected before and after Dexamethasone inhalation by ELISA and fluorescence immunity methods.Results：The levels of ECP,TNF-α and slL-2R were 300±122 μg/L,280±135 ng/L and 497±136 kU/L before Dexamethasone inhalation,and 146±96 μg/L,132±53 ng/L and 328±97 kU/L after Dexamethasone inhalation.Before Dexamethasone inhalation,there were significantly positive correlations between the ECP level and the TNF-α1evels（r=0.58,P0.05） and between the ECP level and the slL-2R levels（r=0.62,P0.05）.No relation was found among them after Dexamethasone inhalation.Conclusion：The decrease of the ECP,TNF-α and slL -2 R levels in sputum after Dexamethasone inhalation can inhibit the inflammatory reaction of respiratory passage in asthmatic patients,indicating that Dexamethasone may be helpful to anti-inflammatory effect in asthmatic patients.

关 键 词：哮喘/病理生理学 哮喘/药物疗法 肿瘤坏死因子/代谢 受体 白细胞介素2/代谢 

分 类 号：R562.25[医药卫生—呼吸系统]