转化生长因子-β1基因+869T/C位点多态性在心房颤动发生中的意义  

Association of gene polymorphism of transforming growth factor-β1 with atrial fibrillation

作　　者：彭健[1] 张忠栋[1] 赖文岩[1] 曾国良[1] 陈良川[1] 邓伟[1] 谭珍妮[1] 

机构地区：[1]南方医科大学南方医院心内科,广州510515

出　　处：《岭南心血管病杂志》2010年第1期25-28,32,共5页South China Journal of Cardiovascular Diseases

基　　金：广东省科技计划项目(项目编号:2008B030301142)

摘　　要：目的研究转化生长因子β1(transforming growth factor-β1,TGF-β1)基因+869T/C多态性与心房颤动(房颤)发生的关系,探索TGF-β1基因+869T/C基因多态性在房颤发生中的意义。方法收集2006年9月至2008年11月心内科住院患者212例,根据有无房颤将患者分为房颤组103例,对照组109例,采用序列特异性引物聚合酶链反应检测TGF-β1基因+869T/C多态性。结果在房颤组中+869T/C位点的CC基因型频率高于对照组,差异有统计学意义(35%vs.19%,P<0.05),+869C等位基因频率高于其对照组,差异有统计学意义(115%vs.90%,P<0.05)。方差分析显示3种基因型的左心房直径差异有统计学意义[(36.54±6.34)mm vs.(39.93±7.70)mm vs.(40.48±7.96)mm;F=5.186,P=0.006],基因型与左心房直径间的关系为:TT<TC<CC。结论TGF-β1+869C基因型是房颤的易感基因型;同时携带TGF-β1+869C等位基因的人群更易患房颤。Objectives To explore the association of genetic polymorphisms of transforming growth factor-β1（TGF-β1） with atrial fibrillation. Methods We collected 212 patients during September 2006 to November 2008 from departments of cardiology. Patients were divided into atrial fibrillation group （n=103） and control group （n=109） according to whether they were with or without atrial fibrillation. Their polymorphism of TGF-β1 gene ＋869T / C was analyzed by sequence specific primers-polymerase chain reaction method. Results Frequencies of TGF-β1 ＋869 CC genotypes in atrial fibrillation group were significantly higher than that in control group （35% vs.19% ,P 〈0.05）. Frequencies of ＋869 C alleles in atrial fibrillation were significantly higher than that in control group （115% vs. 90%,P 〈0.05）.Analysis of variance indicated that left atrial diameters of the 3 genotypes were significantly difference [（36.54±6.34）mm vs.（39.93±7.70）mm vs.（40.48±7.96） mm;F=5.186,P=0.006].The relationship between genotype and left atrial diameter：TT〈 TC〈 CC. Conclusions TGF-β1＋869CC genotype may be a susceptible factor to atrial fibrillation. The patients carrying TGF-β1 ＋869 C alleles are more susceptible to atrial fibrillation.

关 键 词：心房颤动 转化生长因子Β1 基因多态性 

分 类 号：R541.75[医药卫生—心血管疾病]