骨康宁抗骨质疏松药理研究  

Pharmacodynamics study of Gukangning on osteoporosis

作　　者：岳南[1] 李勇[1] 只德广[1] 赵益桂[1] 苏雅[1] 

机构地区：[1]天津药物研究院新药评价中心,天津300193

出　　处：《药物评价研究》2010年第1期51-57,共7页Drug Evaluation Research

摘　　要：目的:观察骨康宁对骨质疏松的防治作用。方法:采用im地塞米松(DEX)导致大鼠形成骨质疏松。结果:与模型对照组比较,骨康宁明显升高骨质疏松大鼠的骨质量、骨密度、骨强度、骨体积(TBV)、灰质量、骨钙、骨磷,明显降低尿钙。结论:骨康宁对大鼠骨质疏松具有明显的防治作用。Objective： To investigate preventive and therapeutic effect of Gukangning on osteoporosis induced by dexamethasone （DEX）. Methods： Osteoporosis was induced by im injection of DEX in rats, Results： Experiments showed that Gukangning could evidently increase bone weight, bone mineral density, bone strength, TBV, ash weight, bone calcium, and bone phosphorus, and decrease urine calcium as well. Conclusion： Gukangning has remarkably preventive and therapeutic effects on osteoporotic in rats.

关 键 词：地塞米松 骨康宁 骨质疏松 药效学 

分 类 号：R681[医药卫生—骨科学]