呼吸系统疾病就诊患者嗜肺军团菌感染的流行病学调查  

Epidemiological Investigation of Legionella pneumophila Infection in Patients with Respiratory Diseases

作　　者：路凤[1] 程义斌[1] 王仲[2] 刘晓清[3] 林江涛[4] 孙永昌[5] 王浩彦[6] 金银龙[1] 

机构地区：[1]中国疾病预防控制中心环境与健康相关产品安全所,北京100050 [2]中国医学科学院北京协和医学院北京协和医院急诊科,北京100730 [3]中国医学科学院北京协和医学院北京协和医院感染内科,北京100730 [4]中日友好医院呼吸内科,北京100029 [5]首都医科大学附属北京同仁医院呼吸内科,北京100730 [6]首都医科大学附属北京友谊医院呼吸内科,北京100050

出　　处：《环境与健康杂志》2010年第3期203-205,共3页Journal of Environment and Health

基　　金：国家"十一五"科技支撑课题(2006BAI19B04)

摘　　要：目的了解呼吸系统疾病就诊患者嗜肺军团菌(Legionella pneumonia,Lp)的感染情况并研究其影响因素。方法于2008年3—6月,以北京4家大型综合性医院的呼吸系统疾病就诊患者为研究对象,进行问卷调查和血清嗜肺军团菌抗体的测定。结果 493名呼吸系统疾病就诊患者中,共22例Lp1～7IgG抗体阳性,抗体总阳性率为4.5%;多元Logistic回归分析显示,年龄、是否曾使用集中空调、免疫抑制剂应用史为嗜肺军团菌感染的影响因素。结论呼吸系统疾病就诊患者存在嗜肺军团菌的隐性感染,老年人(≥60岁)、接触集中空调及应用免疫抑制剂是人群嗜肺军团菌感染的危险因素。Objective To investigate the status of Legionellapneumophila infection in patients with respiratory diseases, and to study the influencing factors for LegioneUa pneumophila infection. Methods During the period of March to June 2008,493 patients with respiratory diseases were selected in four large general hospitals in Beijing, the epidemiological investigation and detection of serum Lp 1-7 IgG were conducted. Results All the selected 493 patients underwent the serologic examination, in 22 of whom serum Lp1-7 IgG showed positive, with a seroprevalence of 4.5 %; Multiple logistic regression analysis showed that age, using central air-conditioning and immunosuppressive agents were significantly related to the Legionella pneumophila infection. Conclusion There is a number of patients with Legionella pneumophila inapparent infection among the patients visiting hospital for respiratory diseases, and the aged people, using central air-conditioning and immunosuppressive agents are the risk factors of Legionella pneumophila infection.

关 键 词：嗜肺军团菌 流行病学 血清抗体 

分 类 号：R181.3[医药卫生—流行病学]