理气调补汤对运动性疲劳大鼠血清β内啡肽和白细胞介素2影响的研究  

Effect of Liqi Tiaobu Decoction on Fatigued Rats Induced by Exercise

作　　者：王丛笑[1] 方素萍[2] 马丽华[1] 周军[1] 

机构地区：[1]首都体育学院,北京100088 [2]广安门医院分子生物室,北京100053

出　　处：《现代生物医学进展》2010年第4期646-648,共3页Progress in Modern Biomedicine

基　　金：北京市教育委员会人才强教项目资助课题(PXM2008-014206-053361)

摘　　要：目的:通过观察理气调补汤对运动性疲劳大鼠血清β内啡肽和白细胞介素2水平的影响,以期揭示中药理气调补汤促进运动性疲劳恢复的作用机理。方法:健康雄性SD大鼠30只,随即分为对照组(Ⅰ组)8只、单纯运动组(Ⅱ组)11只、中药运动组(Ⅲ组)11只。实验时Ⅲ组每天定时定量中药灌胃1ml/100g体重,Ⅰ组、Ⅱ组灌胃相同剂量的生理盐水。实验采用游泳运动训练方式。6周末力竭训练后24h分离血清测定β内啡肽和白细胞介素2含量。结果:Ⅲ组大鼠游泳至力竭的时间较Ⅱ组显著延长;Ⅱ组和Ⅲ组大鼠血清IL-2浓度均显著低于Ⅰ组,但Ⅲ组大鼠血清IL-2浓度显著高于Ⅱ组;血清β-EP浓度Ⅱ组显著高于Ⅰ组,Ⅲ组较Ⅱ组显著降低。结论:理气调补汤可纠正疲劳造成的大鼠机体生理平衡状态的紊乱,提高运动性疲劳大鼠的运动能力,延缓疲劳的发生。Objective： To discuss the effect of Liqi Tiaobu Tang decoction on the anti-exercise fatigue through observing the influence of the Liqi Tiaobu Tang decoction to content of serum beta-endorphin （βEP） and IL-2 in the rat of fatigue induced by exercise. Methods： 30 male SD mice were randomly divided into 3 groups： control group （group Ⅰ）, exercise group （group Ⅱ）, medicine group （group Ⅲ）. Group Ⅲ affuses stomach every day with the certain dosage Liqi Tiaobu Tang. Group Ⅰand Ⅱaffuse stomach every day with the certain dosage Saline. Ⅰand Ⅱ groups are all trained for 6 weeks with swimming training method. By the end of the 6th week , all rats were killed on 24 hours after training. Separate serum and Test the content of βEP and IL-2. Results： The time of group Ⅲ rats swimming to exhaustion was significantly prolonged compared with Group Ⅱ.Compared with the control group, levels of IL-2 in group Ⅱand Ⅲ were markedly decreased, but levels of IL-2 in groupⅢare higher than groupⅡ. Compared with groupⅡ, content of βEP in groupⅠand Ⅲ were significantly enhanced. Conclusion： Liqi Tiaobu Tang can correct the physiological balance disorder caused by overtraining. improve exercise capacity of the rat of fatigue Induced by exercise and delay the occurrence of fatigue.

关 键 词：理气调补汤 运动性疲劳 血清 Β内啡肽 白细胞介素2 

分 类 号：Q95-3[生物学—动物学] R285.5[医药卫生—中药学]