定量药理学在新药研发及临床治疗药物监测方面的应用  

Application of pharmacometrics in drug development and therapeutic drug monitoring

作　　者：尚德为[1] 王曦培[1] 邓晨辉[1] 毕姗姗[1] 管峥[1] 周田彦[1] 卢炜[1] 

机构地区：[1]北京大学天然药物及仿生药物国家重点实验室,北京100191

出　　处：《中国药科大学学报》2010年第1期91-96,共6页Journal of China Pharmaceutical University

摘　　要：定量药理学是上个世纪末在传统的药动学基础之上形成的新型学科,其主要运用数学及统计学的方法定量描述、解释和预测药物在体内的作用行为。近年来定量药理学中涉及的模型化和仿真预测在新药研发、治疗药物监测和临床个体化用药等方面得到了广泛的重视和研究。本文主要从新药研发和临床治疗药物监测这两个方面综述了定量药理学国内外研究进展。Pharmacometrics,developed from the conventional pharmacokinetics,is the science of applying mathematical and statistical methods to characterize,understand,and predict a drug＇s pharmacokinetic,pharmacodynamic,and biomarker-outcome behaviors.Pharmacometrics has been widely valued for its utility of modeling and simulation in drug research and development,therapeutic drug monitoring and individualized therapy.This paper reviewed the advances of pharmacometrics employed in new drug research and development and therapeutic drug monitoring both at home and abroad.

关 键 词：定量药理学 新药研发 治疗药物监测 个体化给药 

分 类 号：R969.1[医药卫生—药理学]