得生丸质量标准研究  

Quality Standard of Desheng Pills

作　　者：王荣红[1] 俞嘉[1] 熊志立[1] 李宁[1] 王姝[1] 李发美[1] 

机构地区：[1]沈阳药科大学药学院,沈阳市110016

出　　处：《中国药房》2010年第15期1387-1389,共3页China Pharmacy

基　　金：<中国药典>2010版(一部)标准研究课题(ZN-152)

摘　　要：目的:建立得生丸的质量标准。方法:采用薄层色谱(TLC)法对得生丸中益母草、柴胡和木香进行定性鉴别;采用高效液相色谱(HPLC)法对制剂中芍药苷进行含量测定。结果:益母草、柴胡和木香的TLC斑点清晰。芍药苷进样浓度在1.40～28.0μg·mL-1范围内与峰面积积分值呈良好线性关系(r=0.9990);平均回收率为99.4%,RSD=1.5%(n=9)。结论:所建标准可用于得生丸的质量控制。OBJECTIVE：To establish the quality standard of Desheng pills. METHODS：The components Leonurus japonicus,Bupleurum chinense and Aucklandia lappa in Desheng pills were qualitatively identified by TLC,and the content of peoniflorin in Desheng pills was determined by HPLC. RESULTS：The TLC spots of L. japonicus,B. chinense and A. lappa were clear. The linear range of peoniflorin was 1.40～28.0 μg·mL-1（r=0.999 0） with an average recovery of 99.4%（RSD=1.5%,n=9）. CONCLUSION：The established standard can be used for the quality control of Desheng pills.

关 键 词：得生丸 质量标准 薄层色谱法 高效液相色谱法 

分 类 号：R283.64[医药卫生—中药学] R927.1[医药卫生—中医学]