重症肺炎的抗菌药物降阶梯治疗策略与替考拉宁的临床应用  

Deescalation Therapy for Severe Nosocomial Pneumonia and Clinical Using of Teicoplanin

作　　者：高炜[1] 高景[1] 邢丽华[1] 李振华[1] 王宁[1] 焦婧[1] 

机构地区：[1]郑州大学第一附属医院呼吸内科,河南郑州450052

出　　处：《中华医院感染学杂志》2010年第7期998-1000,共3页Chinese Journal of Nosocomiology

摘　　要：目的使用降阶梯方案治疗重症监护病房(ICU)重症肺炎评价其疗效。方法回顾分析医院2008年8月1日~2009年3月31日ICU重症肺炎患者83例,分成传统治疗组和降阶梯治疗组,比较两组患者的初始治疗恰当率、感染控制率和感染控制所需时间等指标。结果降阶梯治疗组与传统治疗组的初始治疗恰当率为81.37%与55.07%,差异有统计学意义(P<0.05),治疗有效率81.0%与56.1%,差异有统计学意义(P<0.05),感染控制所需天数(7.7±2.4)d与(18.3±5.8)d,差异有统计学意义(P<0.05)。结论对于ICU重症肺炎使用降阶梯治疗可获得良好疗效。OBJECTIVE To use deesealation therapy for the severe nosoeomial pneumonia in the ICU, and estimate the curative effect. METHODS All of 83 patients of severe nosocomial pneumonia from Arg 1st, 2008 to Mar 31st, 2009 were divided into two groups （traditional group and deescalation group）. Their adequate rate of initial therapy, infection controlled rate and the days from the on-set of treatment to the infection controlled were compared. RESULTS Between deescalation group and traditional group, the adequate rate of initial therapy was 81.37% vs 51.07%, respectively, P^0.05. The infection controlled rate was 81.0% vs 56. 1%, respectively, P〈0.05. The days from the onset of treatment to the infection controlled were 7. 7±2. 4 vs 18. 3 ± 5. 8, respectively, P〈0.05. CONCLUSIONS Using deescalation therapy in ICU for severe nosocomial pneumonia have better curative effect.

关 键 词：降阶梯治疗 重症监护病房 重症肺炎 替考拉宁 

分 类 号：R978.1[医药卫生—药品]