脑膜脓毒性金黄杆菌医院感染的耐药性变迁及临床对策  

Drug Resistance of Chryseobacterium meningosepticum:Dynamics and Clinical Antimicrobial Strategy

作　　者：陈洁[1] 潘景业[1] 王瑜敏[1] 王晓蓉[1] 马继红[1] 

机构地区：[1]温州医学院附属第一医院ICU,浙江温州325000

出　　处：《中华医院感染学杂志》2010年第7期1025-1027,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨脑膜脓毒金黄杆菌医院感染的耐药性及其变迁，为临床合理用药提供依据。方法对医院2005年1月～2008年12月住院患者各种标本中分离到的脑膜脓毒金黄杆菌247株，采用17种抗菌药物进行药敏试验，并比较4年的变迁情况。结果美罗培南、氨苄西林、氨苄西林／舒巴坦、氨曲南、头孢曲松、头孢唑林、呋喃妥因、庆大霉素、亚胺培南／西司他丁、头孢他啶、妥布霉素的耐药率均〉90．00％；耐药率较低的有左氧氟沙星（10．12％）、复方新诺明（11．34％）、环丙沙星（9．13％），但三者均出现一定上升趋势；最敏感的足头孢哌酮／舒巴坦（4．02％）、哌拉西林／他唑巴坦（2．43％）。结论医院感染脑膜脓毒性金黄杆菌的对抗菌药物耐药率呈逐年上升趋势，且对多种抗菌药物具有高度耐药性，应加强监测，根据药敏试验选用合理抗菌药物。OBJECTIVE To investigate the change in antibiotic resistance of Chryseobacterium rneningosepticum in hospital for reference of clinical antimicrobial strategy. METHODS Data were collected of the 247 bacteria strains isolated from clinical specimens from Jan 2005 to Dec 2008. Drug sensitivity tests were made for 17 antimicrobial agents. RESULTS A lot of the drug resistance rates were higher than 90.00%, including meropenem, ampicillin, ampicillin/sulbactam, aztreonam, ceftriaxone, cefazolin, furadantin, gentamicin, tienam, ceftazidime and tobramycin. That of the others such as levofloxaein （10. 12%）, trimethoprim/sulfamethoxazole （11. 34~）, ciprofloxacin （9. 13%） were lower and had certain trend of escalation. But the resistance rate to sulperazone （4.02% ） and piperacillin/tazobactam （2.43 %） was the lowest. CONCLUSIONS The resistance to the most of the antibiotics is increasing in clinical specimens. Antimicrobial treatment should be guided by drug sensitivity test.

关 键 词：脑膜脓毒金黄杆菌 医院感染 耐药性 

分 类 号：R378[医药卫生—病原生物学]