慢性阻塞性肺疾病急性加重期患者病原体检测分析  

Dection and analysis of pathogens in patients with acute exacerbation of chronic obstructive pulmonary disease

作　　者：石宝平[1] 钱叶长 王丽华[3] 张有志[1] 周丽[1] 程克文[1] 陈小东[1] 

机构地区：[1]复旦大学附属华山医院宝山分院,上海200431 [2]上海市宝山区中心医院 [3]上海市第一人民医院宝山分院

出　　处：《山东医药》2010年第15期18-20,共3页Shandong Medical Journal

基　　金：上海市宝山区科委资助项目(08-E-19)

摘　　要：目的了解慢性阻塞性肺疾病病情急性加重期患者(AECOPD)的病原学特点,为进一步提高其诊治水平提供思路。方法对165例AECOPD患者行痰细菌定量培养,血清支原体、衣原体、嗜肺军团菌抗体检测以及鼻咽拭子病毒RT-PCR检测,分析其特点。结果病原体检测阳性率为70.3%(116/165)。其中痰检细菌阳性率为47.3%;非典型病原体阳性率为21.2%;病毒检测阳性率为24.8%;细菌和非典型病原体均为阳性21例,阳性率为12.7%;细菌和病毒均为阳性17例,阳性率为10.3%。结论AECOPD患者病原体以细菌最为常见,以革兰阴性杆菌为主,非典型病原体多与细菌混和感染,病毒感染多见于呼吸困难的患者。非感染因素导致的AECOPD病情加重不容忽视。Objective To investigate the pathogenic characteristics in patients with acute exacerbation of chronic obstructive pulmonary disease（ AECOPD）, so as to provide thinking for the development for its consultation. Methods One hundred and sixty-five patients with AECOPD were performed with quantitative sputum bacteria culture, mycoplama pneumoniae, chlamydia pneumoniae and legionella pneumophila specific antibodies test and RT-PCR virus detection. Characteristics of pathogens distribution were studied. Results The positive rate of pathogens were 70.3% （116/165）. In which the positive rate of quantitative sputum bacteria culture was 47.3%, the mycoplama pneumoniae was 21.2%, the vires was 24.8%, the bacteria and atypical pathogen in 21 cases were both positive ,the positive rate was 12.7% ;The bacteria and vires in 17 cases were both positive, the positive rate was 10.3%. Conclusions Bacteria is the the most common pathogens in patients with AECOPD,gram-negative bacteria is the majority, atypical pathogen are often mixed with bacteria. The infection of virus are often seen in dyspnea patients with AECOPD. Non-infection induced AECOPD should be payed great attention to.

关 键 词：慢性阻塞性肺病 病原体 

分 类 号：R563[医药卫生—呼吸系统]