非器官特异性自身抗体对慢性丙型肝炎抗病毒疗效的影响  

Influence of NOSA for Efficiency of Antiviral Therapy of Patients with Chronic Hepatitis C

作　　者：潘闻[1] 张世斌[1] 王贞彪[1] 

机构地区：[1]首都医科大学附属北京佑安医院消化一科,北京100069

出　　处：《中国误诊学杂志》2010年第12期2776-2777,共2页Chinese Journal of Misdiagnostics

摘　　要：目的:观察非器官特异性自身抗体对慢性丙型肝炎抗病毒疗效的影响。方法:回顾性分析慢性丙型肝炎合并自身抗体阳性患者32例,以同期住院的年龄及性别相匹配的自身抗体阴性患者32例作为对照,观察其治疗结束病毒应答(ETVR)、复发(Relapse)及持续病毒应答(SVR)。结果:观察组及对照组ETVR、SVR分别为78.1%、71.9%及59.4%、53.1%。具有统计学差异。结论:自身抗体阴性的慢性丙型肝炎患者对干扰素联合利巴韦林治疗比合并自身抗体阳性患者具有更好的疗效。Objective：To observe the influence of NOSA for the efficiency of antiviral therapy of patients with chronic hepatitis C.Methods：To analyse retrospectively the data of 32 patients with chronic hepatitis C combined with the positive of autoantibodies and 32 patients with chronic hepatitis C combined with the negative of autoantibodies,and to observe the end of treatment virus response（ETVR）,the relapse and the sustained virus response（SVR）.Results：The ETVR and SVR were 78.1%、71.9% and 59.4%、53.1% respectively in observation group and control group.There was a statistic difference.Conclusion：Interferon combined with ribavirin has better efficiency in patients with the chronic hepatitis C combined with the negative of autoantibodies than the patients with chronic hepatitis C combined with the positive of autoantibodies.

关 键 词：自身抗体 肝炎 丙型/药物疗法 慢性病 治疗结果 

分 类 号：R512.63[医药卫生—内科学]