A system for evaluation of ultrasound contrast agent's enhancement effect  

一个用于体外评价超声造影剂显影效果的系统(英文)

作　　者：陈平[1] 杨芳[1] 房坤[1] 顾爱远 钱卓宇[3] 王鹏[4] 顾宁[1] 

机构地区：[1]东南大学江苏省生物材料与器件重点实验室,南京210096 [2]贝尔森影像技术有限公司,无锡214093 [3]东南大学影像科学与技术实验室,南京210096 [4]江苏省计量科学研究院,南京210007

出　　处：《Journal of Southeast University(English Edition)》2010年第1期82-86,共5页东南大学学报（英文版）

基　　金：The National Basic Research Program of China (973Program) (No.2006CB933206);the National Natural Science Foundation of China(No.50872021,60725101)

摘　　要：A system for in vitro investigation of ultrasound contrast agent＇s enhancement effect is presented and evaluated. It includes the digital B-mode ultrasound scanner Belson3000A, the tissue-mimicking ultrasound phantoms and the software which is used for image quantitative analysis. The linear range, optimal settings and repeatability of the system are assessed and explored by scanning the ultrasound phantoms with different reflective intensities. The measurements are performed under an acoustic power from 4.8 to 12.3 mW, the scanner centre frequency is 3.5 MH and the gain setting is 50 dB. Both a self-made surfactant encapsulated microbubble and a commercial ultrasound contrast agent are scanned. The results show that the pixel intensity of ultrasonic images increases with the increase in the sound power, and for the stronger reflective phantoms of more particles, the increasing trend is much more evident. The system is optimal for evaluating the microbubble contrast agents＇ enhancement effects. It presents a simple, effective and real-time means for characterizing the enhancement ability of microbubbles.构建并评价了一个用于体外研究超声造影剂显影效果的系统,该系统包括一套数字化B型超声诊断仪Belson3000A、仿组织超声体模和用于图像量化分析的软件.制备了具有不同反射强度的仿组织超声体模,通过对这些体模材料超声成像,研究了B超系统的线性范围、参数设置和系统的重复性等.超声成像设置为:输出声功率为4.8 ～12.3mW,探头的中心频率为3.5MHz,总增益为50dB.利用该系统,对自制备的表面活性剂微气泡和一种商用造影剂进行了显影成像.结果表明超声图像的灰度值随声功率的增加而增大,强反射特性的超声体模成像时,这种增加趋势更明显.该系统适合用于体外评价超声造影剂的显影效果,为体外表征超声微气泡造影剂的显影能力提供了一种简单、有效、实时的评价方法.

关 键 词：MICROBUBBLE ultrasound phantom enhancement imaging optimal settings 

分 类 号：R445.1[医药卫生—影像医学与核医学]