脂联素对2型糖尿病大鼠循环CRP及sICAM-1水平的影响  

Effect of adiponectin on the levels of serum CRP and slCAM-1 in type 2 diabetic rats

作　　者：刘金波[1] 邓华聪[1] 李丙蓉[1] 兰丽珍[1] 郑宏庭[1] 诸葛福媛[1] 吕智美[1] 

机构地区：[1]重庆医科大学附属第一医院内分泌科,400016

出　　处：《中华内分泌代谢杂志》2010年第3期232-234,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（30771038、30370670、30570744）;教育部博士点基金（20050631009）;教育部重点项目（KJ050314）;教育部第二批“春晖计划”;重庆市教委基金渝教科（2003）

摘　　要：通过转染表达人全长脂联素基因的重组腺病毒载体来提高2型糖尿病大鼠血清脂联素水平。结果表明脂联素干预组血清可溶性细胞间黏附分子1（sICAM-1）和C反应蛋白（CRP）水平较糖尿病组明显下降[（18．73±4．66对23．60±4．25）mg／L和（14．91±1．79对19．09±2．95）ng／ml，均P〈0．01]，提示提高循环脂联素水平可改善糖尿病炎症反应状态。Type 2 diabetic rats were treated with recombinant adenovirus expressing human adiponectin （Ad-APN）. The results showed that the levels of both plasma C-reactive protein and soluble intercellular adhesion molecule-1 were significantly decreased in Ad-APN-treated diabetic rats compared with those of diabetic rats [ （ 18.73±4.66 vs 23.60±4.25 ） mg/L and （ 14.91 ± 1.79 vs 19.09±2.95 ） ng/ml, both P〈0.01 ]. These results suggest that increased serum concentration of adiponectin may improve the status of inflammation in diabetes mellitus.

关 键 词：脂联素 C反应蛋白 细胞间黏附分子1 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]