Control of morphology and structure of calcium carbonate crystals by heparin  

作　　者：LIU XinRong ZHU BaoQing SHAO YingYa YANG XinLin 

机构地区：[1]School of Life Science and Technology, Beijing Institute of Technology, Beijing 100081, China [2]School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China

出　　处：《Chinese Science Bulletin》2010年第11期1107-1111,共5页

基　　金：supported by the Beijing Municipal Science & Technology Commission (Grant No. Y0905001000091)

摘　　要：Growth control of calcium carbonate crystal by organic chemicals contributes an important part to its mineralizing mechanism and biomimetic preparation. The influence of heparin (HEP) on morphology and structure of calcium carbonate generated by CaCl2/Na2CO3 solution was studied by a scanning electron microscope, an X-ray diffraction machine, a Fourier transform infrared spectrophotometer and a fluorescent spectrophotometer. The results showed that the calcite formed in the absence of HEP, while the addition of HEP induced changes in the morphology and structure of calcium carbonate crystals. In the presence of 2.5 mg/mL HEP, calcium carbonate was stimulated to grow orientationally, forming a spherical vaterite with a diameter of 1.5 μm. By X-ray diffraction, the contents of vaterite were counted to be 57.43% and 64.9% in the presence of 5 mg/mL and 20 mg/mL HEP, respectively. The resulted CaCO3/HEP microspheres achieved an 80% efficiency for HEP encapsulation. These results may provide novel references for studying the mechanism of biomineralization and the synthesis of HEP-functionalized materials.Growth control of calcium carbonate crystal by organic chemicals contributes an important part to its mineralizing mechanism and biomimetic preparation. The influence of heparin （HEP） on morphology and structure of calcium carbonate generated by CaCl2/Na2CO3 solution was studied by a scanning electron microscope, an X-ray diffraction machine, a Fourier transform infrared spectrophotometer and a fluorescent spectrophotometer. The results showed that the calcite formed in the absence of HEP, while the addition of HEP induced changes in the morphology and structure of calcium carbonate crystals. In the presence of 2.5 mg/mL HEP, calcium carbonate was stimulated to grow orientationally, forming a spherical vaterite with a diameter of 1.5 μm. By X-ray diffraction, the contents of vaterite were counted to be 57.43% and 64.9% in the presence of 5 mg/mL and 20 mg/mL HEP, respectively. The resulted CaCO3/HEP microspheres achieved an 80% efficiency for HEP encapsulation. These results may provide novel references for studying the mechanism of biomineralization and the synthesis of HEP-functionalized materials.

关 键 词：碳酸钙晶体 生长控制 结构 形态 肝素 傅立叶变换红外光谱仪 扫描电子显微镜 高能物理 

分 类 号：O611.3[理学—无机化学]