SDF-1、CXCR4和hs-CRP在儿童急性白血病中的表达  

The expression and relationship of SDF-1,CXCR4 and hs-CRP in childhood acute leukemia

作　　者：李婉丽[1] 杨惠军[2] 郑敏翠[1] 邹爱军[1] 宋国才[1] 蒋小梅[1] 杨海霞[1] 张本山[1] 吴攀[1] 

机构地区：[1]湖南省儿童医院血液科,湖南长沙410007 [2]湖南师范大学医学院微生物学和免疫学教研室,湖南长沙410007

出　　处：《现代肿瘤医学》2010年第4期793-795,共3页Journal of Modern Oncology

摘　　要：目的:检测儿童急性白血病骨髓中CXCR4、血清中SDF-1和hs-CRP的表达情况,探讨其临床意义,以积累临床经验,指导临床工作。方法:选取我院诊治的85例儿童急性白血病作为实验组,留取治疗前的骨髓穿刺标本,应用流式细胞术对其进行CXCR4的检测;留取治疗前的血清,对其进行SDF-1和hs-CRP的表达量的检测。选取同期20例非恶性血液病儿童的骨髓及血清作为对照组,检测骨髓中CXCR4和血清中SDF-1、hs-CRP的含量。比较二组中CXCR4、SDF-1和hs-CRP的表达及不同临床特征的意义。结果:实验组CXCR4、SDF-1和hs-CRP的表达量显著高于对照组,CXCR4、SDF-1和hs-CRP在急性淋巴细胞性白血病患儿和髓外侵润的患儿表达明显增高。在实验组中CXCR4和SDF-1的表达具有正相关性。CXCR4和hs-CRP、SDF-1和hs-CRP的表达未见明显相关性。结论:CXCR4、SDF-1和hs-CRP在白血病患儿血清中高表达,其在疾病发生发展中可能具有重要意义,CXCR4和SDF-1在白血病的发生发展中具有协同作用。Objective：To investigate the expression and relationship of SDF-1,CXCR4 and hs-CRP,in children acute leukemia,Methods：The experimental group included 85 children with acute leukemia,the control group included 20 normal children.The SDF-1,CXCR4 and hs-CRP were detected.Results：The expressions of SDF-1,CXCR4 and hs-CRP were higher in the experimental group than in the control group.The expressions of SDF-1,CXCR4 and hs-CRP were associated with leukemia typing and extramedullary infiltration.There was positive correlation between SDF-1 and CXCR4 in the experimental group.But there were no relationship between SDF-1 and hs-CRP,CXCR4 and hs-CRP in children of acute leukimia.Conclusion：The expressions of SDF-1,CXCR4 and hs-CRP may play important role in children acute leukemia.

关 键 词：白血病 SDF-1 CXCR4 超敏C反应蛋白 病理 

分 类 号：R733.7[医药卫生—肿瘤]