抑郁对老年慢性阻塞性肺疾病患者生存影响的五年随访研究  

To evaluate the impact of depression on 5-year suvival rate of elderly patients with chronic obstructive pulmonary disease

作　　者：龙威[1] 谢娟[2] 唐建国[1] 闫芳娟[1] 张奕翠[1] 张羽[1] 段磊[3] 

机构地区：[1]复旦大学附属上海市第五人民医院急诊科,200240 [2]复旦大学附属上海市第五人民医院呼吸科,200240 [3]复旦大学附属上海市第五人民医院神经内科,200240

出　　处：《中华老年医学杂志》2010年第3期219-221,共3页Chinese Journal of Geriatrics

摘　　要：目的探讨抑郁对老年慢性阻塞性肺疾病（cOPD）患者5年生存率的影响。方法401例符合诊断标准的老年COPD患者纳入研究，进行综合医院抑郁量表（HAD-D）评分，按照是否合并抑郁分为抑郁组和非抑郁组。以患者死亡或者完成5年随访为研究终点，比较两组患者5年生存率。结果Kaplan—Meier分析结果表明，抑郁组患者5年生存率低于非抑郁组（log—rank法，x2=6．94，P〈0．01）；COX比例风险分析表明，抑郁独立于其他因素，与COPD患者死亡相关（HR：1．84，95％CI：1．08～3．11）。结论合并抑郁的老年cOPD患者5年生存率降低，抑郁是老年COPD患者5年生存的独立影响因素。Objective To evaluate the impact of depression on 5-year survival rate of elderly patients with chronic obstructive pulmonary disease （COPD）. Methods From January 2002 to June 2004, a total of 401 elderly inpatients with COPD were enrolled. They were assigned into two groups according to their HAD-D scores： depression group （HAD-D scores≥ 8） and non-depression group （HAD-D scores〈8）. The follow up time was 5 years. Results The 5-year survival rate was lower in depression group than in non-depression group （log-rank test, x2 = 6.94, P〈0.01）. Depression was independently associated with mortality in elderly patients with COPD （HR： 1.84, 95% CI： 1.08 to 3. 11）. Conclusions Depression in elderly COPD patients is associated with poor 5-year survival rate, and it is an independent influencing factor of 5 year mortality.

关 键 词：抑郁 肺疾病 慢性阻塞性 

分 类 号：R563.9[医药卫生—呼吸系统]