泛素连接酶APC/C和SCF复合物与肿瘤的关系  

Relationship of ubiquitin-ligases APC/C and SCF complex to cancer

作　　者：李淑晶[1] 毕海连[1] 伍会健[1] 

机构地区：[1]大连理工大学生命科学与技术学院,大连116024

出　　处：《北京大学学报（医学版）》2010年第2期243-244,F0003,共3页Journal of Peking University:Health Sciences

基　　金：国家自然科学基金(30670409;30771221);国家高技术研究发展计划专项经费(863计划;2006AA02Z120)资助~~

摘　　要：Ubiquitin ligases are an important component in ubiquitination system,which can recognize substrate proteins specially to promote their degradation.Closely related to the generation and development of many tumors,ubiquitin ligases can regulate the growth,differentiation and apoptosis of cells by influencing protein stability,which makes them a potential new target for tumor molecular therapy.There are many kinds of ubiquitin ligases,mainly including APC/C and SCF complex.This article will introduce the structures and functions of these two kinds of ubiquitin ligases and their roles in the tumor generation and development.Ubiquitin ligases are an important component in ubiquitination system,which can recognize substrate proteins specially to promote their degradation.Closely related to the generation and development of many tumors,ubiquitin ligases can regulate the growth,differentiation and apoptosis of cells by influencing protein stability,which makes them a potential new target for tumor molecular therapy.There are many kinds of ubiquitin ligases,mainly including APC/C and SCF complex.This article will introduce the structures and functions of these two kinds of ubiquitin ligases and their roles in the tumor generation and development.

关 键 词：泛素 泛素蛋白连接酶类 肿瘤 

分 类 号：Q78[生物学—分子生物学]