CD4^+ T淋巴细胞功能研究新进展  

Recent Research Advances on Function of CD4^+T Lymphocytes——Review

作　　者：孙君重[1,2] 肖文华[2] 于力[1] 

机构地区：[1]中国人民解放军总医院血液科,北京100853 [2]中国人民解放军总医院第一附属医院肿瘤科,北京100037

出　　处：《中国实验血液学杂志》2010年第2期544-548,共5页Journal of Experimental Hematology

基　　金：国家自然科学基金(编号30670898;30971297);首都医学发展基金(编号2007-2040);国家973项目基金(编号2005CB522400)资助

摘　　要：细胞免疫是人体免疫系统的重要组成部分,在清除癌变组织和病原菌入侵中发挥重大作用。T细胞在细胞免疫中居中心地位。长期以来,T细胞免疫的研究重点主要集中于CD8+细胞毒T细胞,而关于CD4+T细胞功能的研究多限于CD8+细胞毒T细胞的"辅助"功能,或作为调节细胞抑制免疫反应的研究上,而其杀伤和清除肿瘤细胞的作用似乎被忽视。新近的研究表明,特异性CD8+细胞毒T细胞效应在动物实验或临床研究上均未见理想的效果,CD4+T细胞不是功能单一的一类细胞,而是功能复杂的细胞群。CD4+T细胞的功能不仅限于辅助细胞毒T细胞,而且可以协助NK细胞清除和杀灭肿瘤,甚至还具有不依赖于CD8+CTL的肿瘤杀伤作用。CD4+T细胞在机体抗肿瘤免疫中具有重大意义。本文就CD4+T细胞的分类,分化;CD4+T细胞的功能和分泌的细胞因子;CD4+T细胞与肿瘤免疫;CD4+T细胞的肿瘤免疫调节作用及CD4+T细胞的临床研究进行了综述。Cellular immunity is an important component of human immune system and plays a crucial role in the fight against tumor cell or invasive pathogens. Researches on cell-based immunotherapy have long been focused on eliciting tumor-specific CD8 ^＋ cytotoxic T lymphocytes （CTL） because of their potent killing activity and their ability to reject transplanted organs. However, the resulting treatments have been surprisingly poor at inducing complete tumor rejection, in both the experimental models and clinical trials. The CD4 ^＋ T cells has been studied mainly for their role as helpers for CD8 ^＋ CTL, even suggesting that the tumor-specific CIM T regulatory cells could act as suppressors of antitumor responses. Recent studies indicated that CD4 ^＋ T cells are not a pure cell lineage with single function, but a cell population with complex functions. Moreover CD4 ： T cells may not only be helper cells, but also act as potent effector cells or partners with NK cells that can clear a wide variety of tumors. In a word, the antitumor potential of effector CD4 ^＋ T cells might have been underestimated. In this article, the classification and differentiation of CD ^＋ T cells, the function and secreted cytokines of CD4 ^＋ T cells, the CD4 ^＋ T cells and tumor immune, the tumor-immuno regulatory effects of CD4 ^＋ T cells, and clinical researches of CD4 ^＋ T cells are reviewed. Key words cellular immunology; CD4 ^＋ T lymphocyte; immunofunction

关 键 词：细胞免疫 CD4+T淋巴细胞 免疫功能 

分 类 号：R331.144[医药卫生—人体生理学] R392[医药卫生—基础医学]