三合一疗法联合干扰素治疗慢性乙型肝炎的临床研究  

Clinical study on effects of "three in one" iatreusis combined with interferon (IFN) in treatment chronic hepatitis B

作　　者：王守云[1] 王玉华[1] 尚金霞[1] 杨丽敏[1] 杨亚萍[1] 陈寒冬[1] 刘坤[1] 

机构地区：[1]秦皇岛市第三医院,河北秦皇岛066001

出　　处：《中西医结合肝病杂志》2010年第2期69-71,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：河北省科技支撑计划项目(No.072761480)

摘　　要：目的:观察"三合一"疗法联合干扰素(IFN)治疗慢性乙型肝炎(CHB)的疗效。方法:将180例HBeAg阳性CHB患者随机分为两组:治疗组120例,应用"三合一"疗法联合安福隆(IFNα)治疗,即:①中药汤剂"抑毒饮"内服;②中药膏剂"十妙膏"贴敷;③选用WLGY-801型伟力电脑肝病治疗仪低频电脉冲刺激穴位治疗;④联用IFNα5MU,皮下注射,隔日1次。对照组60例,单用IFNα治疗,用量用法同治疗组。两组病例均治疗24周,随访12周,观察两组肝功能、HBV-M、HBVDNA定量等,并进行统计学比较。结果:两组患者治疗24周结束时:治疗组完全应答(CR)17例,部分应答(PR)51例,无应答(NR)51例,总有效率57.14%(68/119);对照组CR4例,PR19例,NR33例,总有效率41.07%(23/56),组间比较,χ2=3.9405,P<0.05,差异有显著性意义。停药后随访12周时,治疗组CR18例,PR50例,总有效率57.14%(68/119);对照组CR4例,PR17例,总有效率37.50%(21/56),组间比较,χ2=5.879,P<0.05,差异有显著性意义。结论:"三合一"疗法联合干扰素具有较好的抑制乙肝病毒复制及恢复肝功能的作用,疗效优于单用干扰素治疗。Objective：To study the therapeutic effects of ＂three in one＂iatreusis combined with IFNα in treatment chronic hepatitis B（CHB）.Methods：A total of 180 CHB patients with HBeAg-positive were randomly divided into two groups.The treated group（n=120）was treated by ＂three in one＂iatreusis and IFNα,and the control group（n=60） was treated by IFNα alone,All the patients were treated for 24 weeks and followed up 12 weeks.At the end of 24 weeks and 12 weeks,liver function,HBV-M and HBV DNA level were tested in all patients.Results：At the end of 24 weeks,the treated group：complete response（CR）n=17,partial response（PR） n=51,non-response（NR） n=51,total effective proportion was 57.14%（68/119）,the control group：CR n=4,PR n=19,NR n=33,total effective proportion was 41.07%（23/56）.At the end of 12 weeks,The treated group：CR n=18,PR n=50,total effective proportion was 57.14%（68/119）,The control group：CR n=4,PR n=17,total effective proportion was 37.50%（21/56）.Conclusion：＂Three in one＂ iatreusis combined with IFNα,which can suppress hepatitis B virus and improve liver function,the therapeutic effects is better than IFNα alone.

关 键 词：肝炎 乙型 慢性 三合一疗法 干扰素 

分 类 号：R512.62[医药卫生—内科学]