依立雄胺对经尿道前列腺电切术中出血的干预研究  

The intervention study of epristeride on intraoperative hemorrhage during transurethral resection of prostate

作　　者：臧光辉[1] 赵燕[2] 臧正明[3] 樊龙昌[4] 

机构地区：[1]山东省烟台市莱阳中心医院泌尿外科,265200 [2]山东省烟台市莱阳中心医院心内科,265200 [3]山东省烟台市莱阳中心医院ICU,265200 [4]华中科技大学同济医学院附属同济医院麻醉科

出　　处：《中国医师进修杂志》2010年第11期20-22,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的评价术前使用依立雄胺对经尿道前列腺电切（TURP）术中出血的影响，并探讨其作用机制，从而寻找一种减少TURP术中出血的新途径。方法选择2006年9月至2008年3月接受手术治疗的良性前列腺增生（BPH）患者102例，按随机数字表法分为两组，试验组52例患者术前口服依立雄胺每日10mg，分2次服用，2个月后行TURP术；对照组50例患者术前不服用药物而直接行TuRP术。术前计算患者的前列腺质量，术后统计术中冲洗液体量、手术时间及切除前列腺组织，计算出血总量、出血指数和出血强度。结果试验组术中出血总量、手术时间、出血指数、出血强度分别为（157．73±68．30）ml、（43．71±6．47）min、（6．25±4．18）ml／g、（2．96±1．17）ml／min，对照组分别为（214．39±76．62）ml、（51．15±7．87）min、（7．82±4．29）ml／g、（4．30±1．38）ml／min，两组比较差异均有统计学意义（P〈0．01或〈0．05）；而试验组和对照组切除前列腺组织分别为（26．37±8．23）g和（29．65±7．21）g，差异无统计学意义（P〉0．05）。结论术前使用依立雄胺能有效减少TURP术中出血量，进而缩短手术时间，降低手术风险。Objective To evaluate the effect of preoperative with epristeride on decreasing intraoperative hemorrhage during transurethral resection of prostate （TURP） and study its mechanism to find out a new way of decreasing intraoperative hemorrhage during TURP. Methods A total of 102 patients with benign prostatic hyperplasia （BPH） during September 2006 to March 2008 underwent TURP were enlisted into study. The patients were divided into two groups ： the experiment group was preoperated with epristeride 5 mg,twiee every day, and were operated 2 months later;the control group were operated under TURP directly after a definite diagnosis. The weight of tissue was recorded before the operation and the volume of irrigating fluid, the operation time and the weight of removed tissue were calculated after the operation to measure the hemoglobin density and calculated the bleeding quantity, bleeding strength and the bleeding index. Results The bleeding quantity was （157.73 ±68.30 ） ml, the operation time was （43.71 ±6.47 ） min, bleeding index was （6.25 ±4.18） ml/g and bleeding strength was （2.96 ±1.17） ml/min in the experiment group, while those in the eontrol group were （214.39±76.62） ml, （51.15± 7.87） min,（7.82±4.29）ml/g,（4.30±1.38 ） ml/min, respectively, there were statistical significance between the two groups （P 〈 0.01 or 〈 0.05 ）. The weight of removed tissue was （26.37 ±8.23） g in the experiment group and （29.65± 7.21 ） g in the control group, there was no statistical significance in comparing the removed tissues between the two groups （P 〉 0.05）. Conclusion Preoperative with epristeride can effectively decrease intraoperative bleeding during TURP, and then shorten the operation time and reduce the risk of operation.

关 键 词：前列腺增生 出血 经尿道前列腺电切术 依立雄胺 

分 类 号：R699[医药卫生—泌尿科学]