人脐带间充质干细胞旁分泌物质的作用及对肝功能衰竭的影响  

Human umbilical cord mesenchymal stem cell-derived paracrine substance and its effect on liver failure

作　　者：孙琳琳(综述)[1] 朱争艳(审校)[1] 

机构地区：[1]天津医科大学三中心临床学院天津市人工细胞重点实验室天津市再生医学与疾病生物治疗工程研究中心,300170

出　　处：《国际生物制品学杂志》2010年第2期100-103,共4页International Journal of Biologicals

摘　　要：脐带间充质干细胞（umbilical cord mesenchymal stem cell, UC-MSC）是从人脐带华尔通胶（Wharton jelly）中分离出的细胞，它可以表达间充质干细胞的表面标志，其生物学特性与骨髓间充质干细胞相似，可以诱导分化为多种细胞。最近国内外学者对UC—MSC的移植及诱导分化治疗进行了大量研究，如在心肌梗死、肾脏及血液系统疾病中的研究。但对UC—MSC旁分泌物质的研究却不多见。此文就UC—MSC的分泌、分化及免疫调节作用、旁分泌物质的作用及对肝功能衰竭的影响和应用前景作一综述。Umbilical cord mesenchymal stem cell （UC-MSC） is isolated from human umbilical cord Wharton jelly, which can express the surface markers of mesenchymal stem cell. UC-MSC is similar to the bone marrow-derived mesenchymal stem cell in the biological characteristics, and can be induced to differentiate into a variety of cells. In the recent years, domestic and foreign scholars have conducted many studies on cell transplantation and induction differentiation therapy of UC-MSC for myocardial infarction, diseases of kidney and blood system. However, the studies on the paracrine of UC-MSC have been rarely reported. In this paper, the secretion, differentiation and immunoregulation of UC-MSC, the effects of paracrine substances, especially on liver failure, and their application prospects are reviewed.

关 键 词：脐带 间质干细胞 肝功能衰竭 旁分泌 间充质干细胞条件培养基 

分 类 号：R722.12[医药卫生—儿科]