105例小儿血液病骨髓纤维化观察  

Observation of myelofibrosis in 105 cases of children hematopathy

作　　者：张美德[1] 陈光华[1] 鄢璞[1] 曾荣新[1] 郑秀霞[1] 彭婧[1] 陈峥嵘[1] 

机构地区：[1]广州市儿童医院病理科

出　　处：《临床与实验病理学杂志》1998年第6期545-546,I070,共3页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的：探讨小儿血液病与骨髓纤维化的关系。方法：检查１０５例患儿骨髓穿刺活体组织。结果：８１例发生不同程度骨髓纤维化。不同疾病的纤维化例数分别为：急性淋巴细胞性白血病５７例，急性非淋巴细胞性白血病１例，急性粒细胞性白血病３例，急性单核细胞性白血病２例，慢性粒细胞性白血病３例，白血病（不能分类）２例，恶性淋巴瘤（淋巴瘤／白血病）１０例，有３例骨髓活检组织中全片呈纤维化改变。经骨髓涂片检查，分别确诊为：急性淋巴细胞性白血病、骨髓增生异常综合征（ＭＤＳ）和再生障碍性贫血。Purpose To investigate the pathological changes of biopsy bone marrow in children hematopathy cases. Methods Observing the biopsy bone marrow under the light microscope. Results Fifty seven of 70 acute lymphatic leukemia cases had myelofibrosis to some extent. 1 of 2 acute non lymphatic leukemia cases had myelofibrosis. All 3 acute granulocytic leukemia cases had myelofibrosis to some extent. 2 of 5 acute monocytic leukemia cases had myelofibrosis. 3 of 4 chronic granulocytic leukemia cases had myelofibrosis. 2 of 3 leukemia cases (cant be classified) had myelofibrosis. 10 of 15 malignant lymphoma (lymphoma/leukemia) had myelofibrosis. In addition, there were 3 cases of biopsy bone marrow proved to be complete myelofibrosis. After bone marrow smear examination, they were respectively diagnosed as acute lymphatic leukemia, MDS and aplastic anemia. Conclusion The secondary myelofibrosis of biopsy bone marrow in children hematopathy cases has prognostic significance.

关 键 词：骨髓纤维化 儿童 血液病 

分 类 号：R725.52[医药卫生—儿科] R725.513[医药卫生—临床医学]