赖诺普利微粒载药量与包封率影响因素研究  

Investigation on the Formulation Factors Influencing Drug Loading Capacity and Encapsulation Efficiency of Lisinopril Loaded Polyvinyl Alcohol Micro-particles

作　　者：吴俊珠[1,2] 王成军[1] 金拓[2] 

机构地区：[1]大理学院药学院,云南大理671000 [2]上海交通大学药学院,上海200240

出　　处：《大理学院学报（综合版）》2010年第2期6-10,共5页Journal of Dali University

基　　金：大理学院科研基金资助项目(2007X39)

摘　　要：目的:考察处方因素对赖诺普利聚乙烯醇微粒(LIS-PVA-MP)载药量与包封率的影响。方法:喷雾干燥法制备LIS-PVA-MP,单因素考察聚乙烯醇(PVA)的醇解度、分子量、浓度和料液中投料比对载药量与包封率的影响,对结果进行单因素方差分析。结果:PVA醇解度、浓度、料液中投料比三个因素的不同水平组的指标均值存在显著性差异(α=0.05),PVA分子量的不同水平组的指标均值无显著性差异(α=0.05)。结论:PVA醇解度、浓度、料液中投料比对微粒载药量与包封率影响显著。Objective： To investigate the formulation factors influencing drug loading capacity and encapsulation efficiency （EE） of lisinopril-loaded polyvinyl alcohol （PVA） micro-particles （LIS-PVA-MP）. Methods： LIS-PVA-MP was prepared by spray-drying and the formulation factors influencing drug loading capacity and EE such as hydrolysis degree （HD） of PVA, molecular weight （Mw） of PVA, concentration of PVA and weight ratio of lisinopri｜ to PVA in the feed solution were investigated by single factor experiments. Results： Differences were analyzed by one-way analysis of variance （ANOVA）. At the 0.05 level, the means are significantly different in the factors such as HD of PVA, concentration of PVA and weight ratio of lisinopril to PVA in the feed solution. However, at the 0.05 level, the means are not significantly different in the factor of Mw of PVA. Conclusion： All of the three factors, HD of PVA, concentration of PVA and weight ratio of lisinopril to PVA in the feed solution, have a significant influence on drug loading capacity and EE of LIS-PVA-MP.

关 键 词：赖诺普利 微粒 载药量 包封率 

分 类 号：R972[医药卫生—药品]