促性腺激素释放激素拮抗剂在体外受精-胚胎移植周期中的临床应用  

Clinical application of gonadotropin releasing hormone antagonist in in vitro fertilization and embryo transfer

作　　者：易艳红[1] 黄睿[1] 吴敬之[1] 黄翠玉[1] 王艳芳[1] 

机构地区：[1]广东省妇幼保健院生殖医学中心,广东广州510010

出　　处：《中国妇幼保健》2010年第12期1653-1655,共3页Maternal and Child Health Care of China

摘　　要：目的：探讨促性腺激素释放激素拮抗剂（gonadotropin releasing hormone antagonist，GnRH—anta）在体外受精-胚胎移植中应用效果。方法：2006年1月～2007年10月在该院生殖中心进行的391个体外受精-胚胎移植周期，分为两组，127个周期为拮抗剂组，与拈抗剂组同日进入周期而采用激动剂长方案促排的264个周期为对照组。对两组患者年龄、促排卵效果、临床妊娠率、并发症等进行比较。结果：两组在平均年龄、受精率、临床妊娠率、种植率、多胎率、异位妊娠率、早期流产率之间差异无统计学意义（P〉0．05）。拮抗剂组促性腺激素（Gn）天数、Gn总量、获卯数、双原核（2PN）胚胎数、冷冻胚胎数明显较对照组要少（P〈0．01）。结论：在体外受精-胚胎移植周期中，GnRH—anta具有安全、有效、方便等优点，为促排卵提供了新选择。Objective ： To explore the effect of gonadotropin releasing hormone antagonist （ GnRH - anta） in in vitro fertilization and embryo transfer （ IVF - ET） . Methods ： 391 cycles of IVF - ET in Center of Reproductive Medicine from January 2006 to October 2007 were divided into antagonist group （ 127 cycles） and control group （264 cycles treated with agonist long protocol） . The age, effect of ovulation induction, clinical pregnancy rate and complications in the two groups were compared. Results： There was no significant difference in average age, fertilization rate, clinical pregnancy rate, implantation rate, multiple pregnancy rate, ectopic pregnancy rate and early abortion rate between the two groups （P 〉 0. 05 ） . The duration of gonadotropin （ day）, total dose of gonadotropin, number of retrieved oocytes, number of 2PN embryos, number of frozen embryos in antagonist group were significantly smaller than those in control group （ P 〈 0. 01 ） . Conclusion ： In cycles of IVF - ET, GnRH - anta is a safe, effective and convenient protocol and produces a new choice for controlled ovarian hyperstimulation.

关 键 词：体外受精 胚胎移植 促性腺激素释放激素拮抗剂 控制性超排卵 

分 类 号：R321.2[医药卫生—人体解剖和组织胚胎学]