离子液体中酮肟O-烷基化反应的研究  

O-Alkylation of Ketone Oxime in Ionic Liquids

作　　者：张胜建[1] 张洪[1] 石园庆[1] 毛红雷[1] 

机构地区：[1]浙江大学宁波理工学院,宁波315100

出　　处：《有机化学》2010年第4期606-610,共5页Chinese Journal of Organic Chemistry

摘　　要：以[Bmim]PF6,[Bmim]BF4,[Bmim]OH为介质,以NaOH为缚酸剂,由酮肟与卤烷、硫酸酯等烷基化剂在20～40℃反应1～2h,以52%～94%的收率制备了酮肟醚衍生物,产物结构经1HNMR,GC-MS表征.结果表明,该方法简便易操作,所用离子液体对环境友好,并可循环使用.A series of ketone oxime ethers were synthesized by O-alkylation of ketone oxime with several alkylating agents such as alkyl halides and alkyl sulfates in ionic liquids. The O-alkylation reactions were conducted in 20-40 ℃ for 1 --2 h, using ionic liquids [Bmim]PF6, [Bmim]BF4 and [Bmim]OH as medium and NaOH as acid binding agent. The yields of 52%-94% were obtained and the products were identified by 1H NMR and GC-MS techniques. The study shows that the operation conditions are mild, the process is simple and green to environment, and the ionic liquids could be reused while maintaining good performance.

关 键 词：离子液体 酮肟 O-烷基化 O-烷基酮肟醚 

分 类 号：O643.32[理学—物理化学]