戊型肝炎患者T淋巴细胞亚群的变化  

Changes of T lymphocyte subsets in patients with hepatitis E

作　　者：计云霞[1] 张春涛[2] 严艳[1] 赵晨燕[2] 牛京勤[1] 郝娃[1] 殷继明[1] 李卓[1] 王佑春[2] 

机构地区：[1]首都医科大学附属北京佑安医院,北京100069 [2]中国药品生物制品检定所

出　　处：《山东医药》2010年第16期2-4,共3页Shandong Medical Journal

基　　金：国家863课题基金资助项目(2006AA02Z453)

摘　　要：目的探讨戊型肝炎患者外周血T淋巴细胞亚群的变化及其免疫学意义。方法应用流式细胞仪检测136例急性戊型肝炎患者及13例正常人群的外周血T细胞亚群。结果戊型肝炎患者与正常人比较,T淋巴细胞亚群变化无统计学差异(P>0.05)。单纯戊型肝炎病毒感染组的CD3+细胞总数、CD4+和CD8+细胞绝对数均高于重叠乙型肝炎病毒感染组(P均<0.05)。结论戊型肝炎病毒感染患者存在宿主细胞免疫功能的改变,这可能与急性戊型肝炎肝细胞损伤和清除病毒有关。Objective To measure the change of T lymphocyte subsets in patients with acute hepatitis E（HE） and evaluate its immunological significance.Methods The levels of T lymphocyte subsets in 136 patients with acute HE and 13 normal controls were measured by using flow cytometry.Results None of the T lymphocyte subsets showed significant difference between the patients with HE and the normal group.The absolute number of CD＋3,CD＋8 and CD＋4 T lymphocyte were significantly increased in patients with solo hepatitis E virus（HEV） infection than those of superinfected with HBV（P0.05）.Conclusion HEV infection may lead to the change of T lymphocyte immune function,which may contribute to the hepatocyte impairment and the clearance of the virus in HEV patients.

关 键 词：T淋巴细胞亚群 流式细胞术 肝炎 戊型 

分 类 号：R512.6[医药卫生—内科学]