泌尿系细菌L型感染致病性临床研究  

Clinical analysis of the pathogenicity of bacteria L-form in recurrent urinary tract infection

作　　者：陈卫东 常保超[1] 杨萍[2] 张燕[1] 刘磊[1] 

机构地区：[1]蚌埠医学院第一附属医院肾病科,安徽蚌埠233000 [2]蚌埠医学院第一附属医院检验科,安徽蚌埠233000

出　　处：《中国微生态学杂志》2010年第4期339-341,共3页Chinese Journal of Microecology

基　　金：安徽省卫生厅科研基金项目(2006B085)

摘　　要：目的探讨泌尿系反复感染致病菌的发病特点及细菌L型感染的致病性,为临床诊治提供科学依据。方法将127例清洁中段尿培养确诊的反复发作肾盂肾炎患者,根据致病菌分为细菌型组、细菌伴L型组和细菌L型组,健康体检者为对照组,分析4组患者尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)、尿视黄醇结合蛋白(RBP)水平变化。结果泌尿系感染各组尿NAG和尿RBP较正常对照组均有不同程度升高,差异有非常显著性(P<0.01),单纯细菌L型感染患者较细菌型及细菌伴L型患者稍低,但细菌型、细菌伴L型及细菌L型3组之间差异无显著性(P>0.05)。结论细菌L型在泌尿道感染反复发作中占重要地位,泌尿系细菌L型感染具有致病性。Objective To explore the clinical peculiarity and the pathogenicity of bacteria L-form in recurrent urinary tract infection,and provide scientific evidences for clinical diagnosis and treatment.Method 127 cases of recurrent pyelonephritis diagnosed by bacterial culture were divided,according to pathogens,into general bacteria group,accompanied bacteria L-form group and bacteria L-form group respectively,with the healthy individuals as the control group. The levels of urinary N-acetyl-beta-D-glocosamidase（NAG） by NAG/urinary creatinine （UCr） and retinoid-binding protein （RBP） were detected.Result The levels of urinary NAG/UCr and RBP in three observed groups were higher than those in healthy control group（P〈0.01）; There were no significant differences between the general bacteria,accompanied bacteria L-form and bacteria L-form groups （P〉0.05）. Conclusion Bacteria L-form （including accompanied L-from bacteria） are the main pathogens in recurrent urinary tract infection. Clinical research demonstrated that bacteria L-form have pathogenicity and play an important in recurrent urinary tract infection.

关 键 词：泌尿道感染 细菌L型 致病性 

分 类 号：R378[医药卫生—病原生物学]