青春期单纯性肥胖儿童颈动脉内中膜厚度与脂联素水平分析  

Association Between Common Carotid Artery Intima-media Thickness and Serum Adiponectin in Simple Obese Adolescents

作　　者：胡小蓉[1] 许诚[1] 张忠新[1] 赵平[1] 

机构地区：[1]江苏省南通市第一人民医院儿科,226001

出　　处：《中国学校卫生》2010年第4期453-454,共2页Chinese Journal of School Health

摘　　要：目的探讨肥胖超重青少年患者血清脂联素等生化指标水平的变化及与颈动脉内中膜厚度的关系,为预防肥胖相关的心血管疾病的发生提供依据。方法测定40名肥胖青少年、37名超重青少年和42名体重正常青少年血清脂联素水平及颈动脉内中膜厚度,分析3组间的水平变化、分析两者间的相互关系。结果肥胖组血浆脂联素水平与超重组、正常对照组比较,明显低于对照组,差异有统计学意义(P<0.05)。肥胖组颈动脉内中膜厚度与超重组、正常对照组比较,差异有统计学意义(P<0.05)。颈动脉内-中膜厚度与脂联素水平呈负相关。结论肥胖青少年血清脂联素水平明显下降,颈动脉内膜厚度增厚,肥胖青少年存在着血管内皮功能障碍,动脉顺应性功能下降。Objective To explore the association between common carotid artery intima-media thickness and serum adiponectin（APN） in simple obese adolescents,and to provide evidence for early prevention. Methods 40 obesity,37 overweight and 42 normal subjects were observed.Their serum levels of APN and common Carotid artery intima-media （IMT） were measured. The changes of the serum APN and IMT were investigated in three groups and relationship between APN and IMT were analyzed. Results The level of APN was obviously lower than overweight and normal group（P〈0.05）. IMT of obesity group was obviously thicker than overweight group and normal group （P〈0.05） and IMT was positively correlated with APN. Conclusion The levels of serum APN in simple obese adolescents are markedly degraded and the IMT are markedly thickened. There are endothelial dysfunction and the decrease of arterial compliance in simple obese adolescents.

关 键 词：脂联素 颈动脉 肥胖症 青春期 儿童 

分 类 号：R589.25[医药卫生—内分泌] R179[医药卫生—内科学]