广泛耐药肺结核患者临床分析  

Extensively drug-resistant tuberculosis

作　　者：张丽[1] 黄汉平[1] 张茜[1] 

机构地区：[1]湖北省武汉市医疗救治中心,武汉430023

出　　处：《临床医学》2010年第3期22-24,共3页Clinical Medicine

摘　　要：目的分析广泛耐药肺结核患者的临床特点,探讨其防治对策。方法将我院收治的938例复治菌阳性的肺结核患者分为两组,42例广泛耐药肺结核患者分类为观察组,其余896例为对照组。治疗方案观察组为个性方案,对照组为3HRZES/9HRE,分别分析两组患者的临床表现、X线表现、药敏、治疗中病灶吸收情况和痰菌阴转情况。结果观察组患者临床症状多且重,耐药广泛,肺部病变广泛,空洞、毁损多见,治疗效果不理想。对照组疗效较理想。结论广泛耐药肺结核患者是一组症状重、病变广且重、耐药广、治疗效果差的特殊肺结核人群,需加大控制结核的力度,正确管理治疗结核,以预防耐药结核的发展和传播。Objective To analyse the clinical characteristics,preventive and treatment methods of extensively drug-resistant tuberculosis.Methods A total of 938 cases were choseed in a randomized way,who were receiving re-treatment for sputum positive tuberculosi,they were divided into the study group（n=42,extensively drug-resistant tuberculosis treated individually） and control group（n=896,treated with 3HRZES/9HRE）.Results The clinical manifestation was more serious and drug-resistance was more extensive in the study group.When the treatment was completed,the focus absorptivity rate and negative conversion rate in the study group were both worse than that in the control group.Conclusion The clinical manifestation of extensively drug-resistant tuberculosisis complex and severe.It is difficult for the treatment of extensively drug-resistant tuberculosis.More attention should be made to according to the principle of standardize chemotherapy regimens and strengthening the management of chemotherapy,in order to reduce the level of drug-resistance.

关 键 词：广泛耐药 肺结核 治疗 

分 类 号：R521[医药卫生—内科学]