伴发代谢综合征精神分裂症患者认知功能变化  

Cognitive change in schizophrenic patients with concomitant metabolism syndrome

作　　者：李钦云[1] 卞清涛[1] 邹义壮[1] 王健[1] 张广慧[1] 王维山[2] 刘小鹏[2] 张守宇[2] 张丽霞[1] 谭云龙[1] 谭淑平[1] 崔界峰[1] 陈楠[1] 范宏振[1] 

机构地区：[1]北京回龙观医院,北京100096 [2]北京老年医院

出　　处：《中华行为医学与脑科学杂志》2010年第4期322-324,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：基金项目：北京市科技计划项目（D0906001040191）

摘　　要：目的探讨伴发代谢综合征精神分裂症患者的认知功能变化。方法对符合入组标准的伴发代谢综合征的住院精神分裂症患者56例和同期住院的精神分裂症患者56例；采用MCCB、Stroop、数字广度、upsa量表进行认知功能测查。结果伴发代谢综合征的精神分裂症患者MCCB中的符号编码、言语记忆、数字序列、迷宫、持续操作[（27．07±10．46）分、（16．04±5．07）分、（13．39±5．18）分、（1．38±0．66）分、（1．23±0．68）分]与对照组[（32．18．4-12．12）分、（18．71±6．02）分、（15．79±5．48）分、（1．7±0．68）分、（1．6±0．74）分]之间均差异有显著性（P〈0．05），stroop和数字广度[（31．14±11．68）分、（13．77±3．64）分]与对照组[（36．57±13．32）分、（15．82±4．38）分]之间也差异有显著性（P〈0．05），均是伴发代谢综合征的患者的认知功能低于对照组。结论伴发代谢综合征的精神分裂症患者比无代谢综合征的精神分裂症患者存在更严重的认知功能的损害。Objective To explore cognitive change in schizophrenic patients with concomitant metabolism syndrome,and to provide theory basis for early intervention and treatment. Methods According to inclusion standard ,56 schizophrenic inpatients with metabolism syndrome and 56 schizophrenic inpatients without metabolism syndrome were included. The matrics consensus cognitive battery （ MCCB ）, stroop test, digit span, UPSA-B were used to assess the cognitive function. Results There were significant differences for test scores of symbol coding subtest,verbal memory subtest,digit sequence subtest, Maze subtest, continue performance among MCCB between schizophrenic patients with and without metabolism syndrome （27.07 ± 10.46 vs 32.18 ± 12.12,16.04 ± 5.07 vs 18.71 ±6.02,13.39 ±5.18 vs 15.79 ±5.48,1.38 ±0.66 vs 1.7 ±0.68,all P〈0. 05） ,as well as stroop test and digit span test （31.14 ± 11.68 vs 36.57 ± 13.32,13.77 ± 3.64 vs 15.82 ± 4.38, P〈 0.05 for both）. Conclusion The schizophrenic patients with metabolism syndrome have severer cognitive impairment than those without metabolism syndrome.

关 键 词：代谢综合征 精神分裂症 认知功能 

分 类 号：R686[医药卫生—骨科学]