抑郁症患者工作记忆损害与磁共振扩散张量成像部分各向异性值相关性的研究  

Correlation between fractional anisotropy values of diffusion tensor imaging and working memory impairment in patients with depression

作　　者：任力杰[1,2] 陆兵勋[1] 吴明祥 韩漫夫[2] 李竞[2] 

机构地区：[1]南方医科大学南方医院神经内科,广州510515 [2]深圳市第二人民医院神经内科 [3]深圳市人民医院放射科

出　　处：《中华行为医学与脑科学杂志》2010年第4期325-327,共3页Chinese Journal of Behavioral Medicine and Brain Science

摘　　要：目的探讨抑郁症患者工作记忆损害与磁共振扩散张量成像部分各向异性值的相关性，分析其合并记忆损害的神经病理基础。方法对30例抑郁症患者和30例年龄及文化程度相当的健康志愿者，采用1-Back工作记忆任务和磁共振扩散张量成像，对2组平均正确反应时和部分各向异性值进行统计学分析。结果与正常对照组平均正确反应时[（612．45±54．08）ms]相比，抑郁症组平均正确反应时[（720．25±57．02）ms]明显延长，差异有显著性（P〈0．01），抑郁症组双侧额叶、扣带回前部、扣带回压部、胼胝体膝部和压部部分各向异性值与健康对照组相比显著下降，差异有显著性（P〈0．05），其中双侧额叶白质部分各向异性值与平均正确反应时呈负相关关系（r=-0．604，P〈0．05）。结论抑郁症患者存在白质区域神经纤维的异常，这可能是抑郁症患者工作记忆损害的的神经病理学基础之一。Objective To investigate whether there are correlations between working memory impairmentand fractional anisotropy values and to explore the neuropathology underlying that the patients of depression suffered from memory impairment. Methods Thirty depression patients and 30 healthy controls group-matched by age,educational level were conducted the study. Mean correct reaction time（toRT） was recorded when they performed a One-Back Working Memory Task and fractional anisotropy （FA） values was recorded when they performed the diffusion tensor imaging. Statistics analysis was done respectively for mRT and FA values between two groups. Results Relative to mean correct reaction time（ （612.45 ± 54.08 ）ms） of controls, the mean correct reaction time （（720.25 ± 57.02 ）ms） of patients with depression was much longer （P 〈 0.05 ） and the patients with depression had a lower FA values in the white matter of both frontal lobe,anterior cingulate gyrus ,supramarginal gyms,splenium of corpus callosum （P 〈 0.05） ,and the FA values in the white matter of both frontal lobe were significantly negative correlated with toRT（ r = - 0. 604, P 〈 0.05）. Conclusion The impairment of white matter region may be one of the neuropathology underlying that the depression patients suffer from memory impairment.

关 键 词：抑郁症 工作记忆 平均正确反应时 扩散张量成像 部分各向异性 

分 类 号：R686[医药卫生—骨科学]