三种浙产特色药材炮制前后微量元素与重金属的含量研究  

Research on the Content of Trace Elements and Heavy Metals in the Three Kinds of Zhejiang Specific Medicinal Materials before and after Processing

作　　者：袁珂[1] 王麟[2] 孙素琴[3] 殷明文[4] 

机构地区：[1]浙江林学院天然药物研发中心,浙江临安311300 [2]河南中医学院药学院,河南郑州450008 [3]清华大学化学系,北京100084 [4]郑州大学化学系,河南郑州450052

出　　处：《光谱学与光谱分析》2010年第5期1400-1403,共4页Spectroscopy and Spectral Analysis

基　　金：浙江省重点科技项目(2007C23024);浙江省森林培育重中之重学科开放基金项目(200607)资助

摘　　要：用微波消解-电感耦合等离子体质谱法(ICP-MS)同时测定了3种浙产特色药材炮制前后Mn,Fe,Cu,Zn,Cr,As,Cd,Pb的含量。该方法的加样回收率在95.2%～106.3%之间,相对标准偏差RSD在0.69%～2.34%之间。试验结果显示,3种药材炮制前后对人体有益的微量元素Mn,Fe,Zn的含量均较高;而有害重金属元素Cu,Cd,Cr,Pb,As的含量均低于《中国药典》的限量标准,炮制加工均使其中的微量元素及重金属含量有所变化,不同的炮制方法在个别元素含量上存在差异。炮制后除Pb的含量明显下降,Cu,As,Cd基本不变外,其他元素的含量均有不同程度的增加,这种差异可能与药材的炮制方法有关。该测定结果为进一步探讨3种浙产特色药材的炮制方法与其功效的相关性提供了科学依据。By establishing the ICP-MS determining method, we determined the contents of Mn, Fe, Cu, Zn, Cr, As, Cd and Pb in the three kinds of ZheJiang specific medicinal materials before and after processing them. The recovery ratio with standard addition of the method is between 95.2%and 106.3, and the relative standard deviation between 0.69%and 2.34%. The results of the experiment show that the contents of useful metals Mn, Fe, Cu and Zn are fairly high both before and after processing, while the contents of harmful heavy metals Cd, Cr, Pb and As are all lower than the limited quantity in the standard of Chinese Pharmacopoeia. After processing, there seems to be some content changes in the trace elements and heavy metals. Different content changes depend on different processing methods. After processing, except the notable decrease in Pb, the contents of Cu, As and Cd are almost constant, while the contents of other elements are nearly all increased. The result seems to be related with the methods of processing. This experimental result provides us with new scientific foundation for the further research on the relationship between different processing methods and different efficacy of the three specific Zhejiang medicinal materials.

关 键 词：微波消解 电感耦合等离子体质谱法 特色药材 微量元素 重金属 

分 类 号：R284.1[医药卫生—中药学]