新生儿缺氧缺血性脑病患儿血清白介素-1α与白介素-1β的变化及临床意义  

Study on the Clinical Significance of Changes of Serum Interleukin-1α and Interleukin-1β in Neonates with Hypoxis Ischemic Encephalopathy

作　　者：杨铭华 阚秀梅 魏校敏 刘旭欣 李月英 关秀茹[2] 

机构地区：[1]哈尔滨市儿童医院,哈尔滨150010 [2]哈尔滨医科大学附属第一医院实验诊断教研室,哈尔滨150001

出　　处：《现代检验医学杂志》2010年第2期132-134,共3页Journal of Modern Laboratory Medicine

摘　　要：目的探讨新生儿缺氧缺血性脑病（hypoxic ischemic encephalopathy，HIE）患儿血清中白介素-1α（interleukin—a，IL—1α）、白介素-1β（interleukin-β，IL-1β）的变化及临床意义。方法采用ELISA方法于生后3d及7d检测病例纽32例HIE患儿与对照组24例正常新生儿血清中IL-1α以及IL-1β水平。结果生后3d HIE患儿和正常新生儿血清中IL-1α水平分别为8．76±4．07pg／ml，3．95±1．09pg／ml；生后7d分别为5．00±2．12pg／ml，3．52±1．74pg／ml，两者差异均有统计学意义（P〈0．01）。生后3d HIE患儿和正常新生儿血清中IL-1β水平分别为64．00±13．80pg／ml，33．89±18.32pg／ml；生后7d分别为54．30±13．10pg／ml，36．91±18．02pg／ml，两者差异也均有统计学意义（P〈0．01）；生后3d和7d，HIE患儿血清中IL-1α水平随着病情的加重而逐渐升高，差异均有统计学意义（P〈0．01）。生后3d和7d，HIE患儿病情愈严重血清中IL-1β水平升高愈明显，差异均有统计学意义（P〈0．01）。结论新生儿HIE患儿血清中IL-1α和IL-1β水平变化与HIE和脑损伤的严重程度有关，并且在新生儿HIE的发病机理中起重要作用。Objective To explore the neonatal hypoxie ischemic encephalopathy（HIE） in serum interleukin-1α（IL-1α） and interleukin-1β（IL-1β） clinical significance of changes. Methods ELISA methods used in the 3 days after birth and 7 days in case group detected 32 cases of HIE children with the control group, 24 cases of normal neonatal serum IL-1α and IL-1β levels. Results 3 days after birth in children with HIE and normal serum levels of IL-1α were 8. 76±4.07 pg/ml and 3. 95 ±1.09 pg/ml （P〈0. 01）,respectively. 7 days after birth to 5.00±2.12 pg/ml and 3.52±1.74 pg/ml （P〈0. 01）. 3 days after birth in children with HIE and normal serum levels of IL-1β levels were 64. 00±13. 80 pg/ml and 33. 89±18. 32 pg/ ml （P〈0. 01） ,respectively. 7 days after birth to 54.30±13.10 pg/ml and 36.91 ± 18. 02 pg/ml （P〈0.01） ,and with the severity of disease-related. Conclusion The changes of IL-1α and IL-1β level in serum inneonates with HIE is related to the severity of HIE and brain damage. It is suggested that IL-1α and IL-1β might play a role in the pathogenesis of neonatal HIE.

关 键 词：新生儿缺氧缺血性脑病 白细胞介素-1Α 白细胞介素-1Β 

分 类 号：R722.19[医药卫生—儿科] R392.11[医药卫生—临床医学]