血尿酸与冠脉病变的相关性研究  

Association between Serum Uric Acid Level and Coronary Lesions

作　　者：费爱科[1] 龚浩[1] 申国璋[1] 胡威[1] 

机构地区：[1]长沙市第四医院心内一科,湖南长沙410006

出　　处：《中国现代医生》2010年第12期84-85,共2页China Modern Doctor

摘　　要：目的探讨血尿酸水平与冠脉病变的相关性。方法 263例患者根据冠脉造影结果分为对照组(n=98)和冠心病组(n=165,根据冠脉病变支数分为单支病变组、双支病变组和三支病变组)。测定各组血清尿酸水平,比较各组患者的血清尿酸水平和血清尿酸与冠脉病变范围的相关性。结果对照组和冠心病组的尿酸分别为(288.47±62.18)μmol/L和(436.32±65.31)μmol/L,差异有统计学意义(P<0.01),单支病变组、双支病变组、三支病变组尿酸分别为(418.49±58.36)μmol/L、(448.27±60.21)μmol/L、(428.68±59.56)μmol/L,三组之间比较差异无统计学意义(P>0.05)。结论血尿酸水平是冠心病的危险因素之一,但与冠脉病变范围不相关,为临床医生提供警示作用。Objective To explore the association between the serum uric acid level and coronary lesions. Methods We divided 263 patients who underwent coronary angiography into control group（ n=98 ）and coronary atherosclerotic heart disease（CHD） group（n=165） in which patients were,in turn,divided into single-,double- and triple-vessel disease groups according to the number of vessels with significant stenosis. The serum uric acid level was determined,and the serum uric acid levels of different groups and the association between the serum uric acid level and coronary lesions were compared. Results The serum uric acid levels of control group and CHD groups were （288.47±62.18） and （436.32±65.31）lxmol/L,respectively and the serum uric acid levels between the two groups were significantly different（P〈0.01）. The serum uric acid levels of the single-vessel group,double-vessel group and triple-vessel group were （418.49± 58.36）, （448.27± 60.21 ）, （428.68± 59.65）umol/L,respectively and the serum uric acid levels in the three groups were no significantly different（P〉0.05）. Conclusion Serum uric acid is one of risk factors for coronary atherosclerotic heart disease,but is not correlated with coronary lesions,supplying a warning to doctors.

关 键 词：尿酸 冠心病 冠状动脉造影术 

分 类 号：R541.4[医药卫生—心血管疾病]