脂联素与2型糖尿病易感性关系的大样本病例对照研究  

Large sample case-control study of association between adiponectin and susceptibility to type 2 diabetes mellitus

作　　者：杜文聪[1] 叶新华[2] 成金罗[2] 李倩[3] 俞晓芳[4] 马建华[3] 高燕勤[4] 陆莹[1] 曹园园[1] 周玲[1] 

机构地区：[1]南京医科大学公共卫生学院流行病与卫生统计学系,江苏南京210029 [2]南京医科大学附属常州市第二人民医院内分泌科,江苏常州213003 [3]南京医科大学附属南京市第一医院内分泌科,江苏南京210006 [4]南京医科大学第三附属医院内分泌科,江苏仪征211400

出　　处：《南京医科大学学报（自然科学版）》2010年第4期460-463,共4页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金资助(30771858);江苏省自然科学基金资助(BK2007229)

摘　　要：目的:探讨血清脂联素水平与2型糖尿病的相关性。方法:在江苏地区选取新确诊2型糖尿病病例348例,正常对照574例。通过询问和体格检查获取健康状况和生活习惯等资料,采用ELISA法检测血清脂联素水平。结果:2型糖尿病组血清脂联素水平(6.01±2.43)mg/L低于对照组(8.59±2.88)mg/L,其差异有统计学意义(t=14.08,P=0.000);分层分析表明,在不同特征群体中,与血清脂联素高水平者相比,低水平者(小于中位数水平)患2型糖尿病的风险都显著增高,且年龄≤50岁[OR(95%CI):13.80(5.48～34.74)]、吸烟[10.74(5.58～20.68)]、腹型肥胖[7.27(4.55～11.62)]低水平者的OR值居前3位;多因素Logistic回归分析显示,低水平脂联素可能是2型糖尿病的危险因子,血清脂联素水平每降低一个等级(以四分位间距划分等级),发病的风险逐渐增加[OR(95%CI):2.22(1.91～2.58)]。结论:低水平脂联素与2型糖尿病的易感性风险增高之间存在关联。Objective：To survey the relationship between serum adiponectin level and type 2 diabetes mellitus （T2DM）. Methods：348 newly diagnosed patients of T2DM and 574 controls from Jiangsu area were investigated,and the serum adiponectin levels were determined with ELISA. The information of healthy condition and behavior was gotten by examination and inquiry. Results：The serum adiponectin of T2DM group（6.01±2.43 mg/L）was significantly lower than that of control group（8.59±2.88 mg/L）;In stratified analysis,compared with the group with high level of serum adiponectin,the low level groups（less than median level） had more risk of susceptibility to T2DM,and the OR values of age≤50[OR （95% CI）：13.80（5.48-34.74）],smoking[10.74（5.58-20.68）]and abdomen obesity[7.27（4.55-11.62）] were top three; By multiple Logistic regression analysis,the T2DM risk for the low level of serum adiponectin,was increased[OR（95%CI）：2.22（1.91-2.58）] compared with the higher level of serum adiponctin（graded by quartile range）. Conclusion：There was an association between low level of adiponectin and high risk of susceptibility to T2DM.

关 键 词：2型糖尿病 脂联素 病例对照研究 

分 类 号：R587.1[医药卫生—内分泌]